Department of Clinical Medicine, Section for Psychiatry, University of Bergen, N-5020 Bergen, Norway.
Alcohol Alcohol. 2011 Mar-Apr;46(2):170-6. doi: 10.1093/alcalc/agq097. Epub 2011 Jan 27.
To compare the mortality of female alcoholics randomly assigned to the woman-only programme 'Early treatment for Women with Alcohol Addiction' (EWA) versus those who received mixed gender 'Treatment As Usual' (TAU).
Randomized controlled trial involving 2-year follow-up by personal interview and mortality register data through 27 years of 200 women first time treated for alcohol use disorder (AUD; EWA, n = 100 and TAU, n = 100), who were consecutively recruited during 1983-1984. Data from the Causes of Death Register were used to test for mortality differences related to group interaction predictors such as age, inpatient versus outpatient status at intake and 2-year drinking outcome.
Significantly lower mortality was found among younger women who participated in EWA compared with those who received TAU. This difference lasted nearly 20 years after intake to treatment. For women who only needed outpatient treatment, reduced mortality was found in the EWA group, even for older women. Increased mortality was found for TAU women who did not attend the 2-year follow-up compared with those who attended; no such difference was found for EWA women. This indicates different attrition mechanisms in the two groups. Thus, previously reported treatment effects may have been underestimated. EWA was a more comprehensive programme than TAU while also being single gender.
EWA, specifically developed to meet a broad spectrum of problems among women with AUDs, was more effective than TAU, a mixed gender programme. It was not possible to separate whether this was in part because it was a more comprehensive programme, as well as being single gender.
比较将女性酗酒者随机分配到仅限女性的项目“早期治疗女性酒精成瘾”(EWA)与接受混合性别“常规治疗”(TAU)的死亡率。
这是一项涉及 200 名首次接受酒精使用障碍(AUD)治疗的女性(EWA,n=100;TAU,n=100)的 2 年随访的随机对照试验,通过个人访谈和死亡率登记数据进行,随访时间为 27 年。数据来自死因登记处,用于测试与组间相互作用预测因子相关的死亡率差异,如年龄、入院时和 2 年饮酒结局的门诊与住院状态。
与接受 TAU 的女性相比,参加 EWA 的年轻女性死亡率显著降低。这种差异在摄入治疗后近 20 年持续存在。对于仅需要门诊治疗的女性,EWA 组的死亡率降低,即使是年龄较大的女性。与参加 2 年随访的女性相比,未参加 TAU 随访的女性死亡率增加;EWA 女性则没有这种差异。这表明两组的失访机制不同。因此,以前报告的治疗效果可能被低估了。EWA 是一个比 TAU 更全面的项目,同时也是单一性别项目。
EWA 是专门为满足 AUD 女性的广泛问题而开发的,比 TAU 更有效,TAU 是一个混合性别的项目。无法确定这是否部分是因为它是一个更全面的项目,以及它是单一性别的项目。