临床干预措施下肺炎链球菌的快速进化。
Rapid pneumococcal evolution in response to clinical interventions.
机构信息
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
出版信息
Science. 2011 Jan 28;331(6016):430-4. doi: 10.1126/science.1198545.
Abstract
Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes encoding major antigens frequently affected. Among these were 10 capsule-switching events, one of which accompanied a population shift as vaccine-escape serotype 19A isolates emerged in the USA after the introduction of the conjugate polysaccharide vaccine. The evolution of resistance to fluoroquinolones, rifampicin, and macrolides was observed to occur on multiple occasions. This study details how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales.
摘要
先前，对具有自然转化能力的细菌病原体肺炎链球菌的流行病学研究受到高重组率的困扰。对 PMEN1（西班牙（23F）-1）多药耐药谱系的 240 个分离株进行测序，使碱基替换能够与通过水平序列转移产生的多态性区分开来。检测到超过 700 次重组，基因编码的主要抗原经常受到影响。其中包括 10 次荚膜转换事件，其中一次伴随着人群转移，在美国引入结合多糖疫苗后，疫苗逃逸血清型 19A 分离株出现。观察到对氟喹诺酮类、利福平、和大环内酯类的耐药性多次发生。本研究详细说明了重组细菌谱系内的基因组可塑性如何能够允许在非常短的时间内适应临床干预。
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