临床干预措施下肺炎链球菌的快速进化。
Rapid pneumococcal evolution in response to clinical interventions.
机构信息
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
出版信息
Science. 2011 Jan 28;331(6016):430-4. doi: 10.1126/science.1198545.
Abstract
Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes encoding major antigens frequently affected. Among these were 10 capsule-switching events, one of which accompanied a population shift as vaccine-escape serotype 19A isolates emerged in the USA after the introduction of the conjugate polysaccharide vaccine. The evolution of resistance to fluoroquinolones, rifampicin, and macrolides was observed to occur on multiple occasions. This study details how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales.
摘要
先前，对具有自然转化能力的细菌病原体肺炎链球菌的流行病学研究受到高重组率的困扰。对 PMEN1（西班牙（23F）-1）多药耐药谱系的 240 个分离株进行测序，使碱基替换能够与通过水平序列转移产生的多态性区分开来。检测到超过 700 次重组，基因编码的主要抗原经常受到影响。其中包括 10 次荚膜转换事件，其中一次伴随着人群转移，在美国引入结合多糖疫苗后，疫苗逃逸血清型 19A 分离株出现。观察到对氟喹诺酮类、利福平、和大环内酯类的耐药性多次发生。本研究详细说明了重组细菌谱系内的基因组可塑性如何能够允许在非常短的时间内适应临床干预。
相似文献
1
Rapid pneumococcal evolution in response to clinical interventions.
Science. 2011 Jan 28;331(6016):430-4. doi: 10.1126/science.1198545.
2
Population structure and drug resistance patterns of emerging non-PCV-13 Streptococcus pneumoniae serotypes 22F, 15A, and 8 isolated from adults in Ontario, Canada.
Infect Genet Evol. 2016 Aug;42:1-8. doi: 10.1016/j.meegid.2016.04.007. Epub 2016 Apr 9.
3
CIRCULATING CLONAL COMPLEXES AND SEQUENCE TYPES OF STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A WORLDWIDE: THE IMPORTANCE OF MULTIDRUG RESISTANCE: A SYSTEMATIC LITERATURE REVIEW.
Expert Rev Vaccines. 2021 Jan;20(1):45-57. doi: 10.1080/14760584.2021.1873136. Epub 2021 Feb 17.
4
Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in Malawi.
Vaccine. 2017 Aug 16;35(35 Pt B):4594-4602. doi: 10.1016/j.vaccine.2017.07.009. Epub 2017 Jul 12.
5
The changing epidemiology of Streptococcus pneumoniae serotype 19A clonal complexes.
J Infect Dis. 2011 May 15;203(10):1345-7. doi: 10.1093/infdis/jir056. Epub 2011 Mar 11.
6
Emergence of 19A as virulent and multidrug resistant Pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccine.
Pediatr Infect Dis J. 2007 Jun;26(6):468-72. doi: 10.1097/INF.0b013e31803df9ca.
7
International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact.
EBioMedicine. 2019 May;43:338-346. doi: 10.1016/j.ebiom.2019.04.021. Epub 2019 Apr 16.
8
Epidemiological and molecular characterization of Streptococcus pneumoniae carriage strains in pre-school children in Arkhangelsk, northern European Russia, prior to the introduction of conjugate pneumococcal vaccines.
BMC Infect Dis. 2020 Apr 15;20(1):279. doi: 10.1186/s12879-020-04998-5.
9
Streptococcus pneumoniae Serotypes 9 and 14 Circulating in Brazil over a 23-Year Period Prior to Introduction of the 10-Valent Pneumococcal Conjugate Vaccine: Role of International Clones in the Evolution of Antimicrobial Resistance and Description of a Novel Genotype.
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6664-6672. doi: 10.1128/AAC.00673-16. Print 2016 Nov.
10
Changes in capsule and drug resistance of Pneumococci after introduction of PCV7, Japan, 2010-2013.
Emerg Infect Dis. 2014 Jul;20(7):1132-9. doi: 10.3201/eid2007.131485.
引用本文的文献
1
Evolving genomic landscape of pediatric pneumococcus in two Canadian urban centers following conjugate vaccination.
Front Microbiol. 2025 Aug 18;16:1642658. doi: 10.3389/fmicb.2025.1642658. eCollection 2025.
2
Naturally competent bacteria and their genetic parasites-a battle for control over horizontal gene transfer?
FEMS Microbiol Rev. 2025 Jan 14;49. doi: 10.1093/femsre/fuaf035.
3
High Propensity for Multidrug-Resistant Pneumococcal Shedding Among Adults Living With HIV on Stable Antiretroviral Therapy in Malawi.
Open Forum Infect Dis. 2025 Jul 16;12(8):ofaf422. doi: 10.1093/ofid/ofaf422. eCollection 2025 Aug.
4
Amoxicillin-non-susceptible causing invasive pneumonia: serotypes, clones, and clinical impact.
Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0023725. doi: 10.1128/aac.00237-25. Epub 2025 Jul 8.
5
dTOURS: Dense-region tagging for outbreak detection using ratio statistics.
PLoS One. 2025 May 13;20(5):e0322663. doi: 10.1371/journal.pone.0322663. eCollection 2025.
6
Genomic characterization of isolates obtained from carriage and disease among paediatric patients in Addis Ababa, Ethiopia.
Microb Genom. 2025 Mar;11(3). doi: 10.1099/mgen.0.001376.
7
Exploring SNP filtering strategies: the influence of strict vs soft core.
Microb Genom. 2025 Jan;11(1). doi: 10.1099/mgen.0.001346.
8
Homologous recombination shapes the architecture and evolution of bacterial genomes.
Nucleic Acids Res. 2025 Feb 8;53(4). doi: 10.1093/nar/gkae1265.
9
Integrating Genomic Data with the Development of CRISPR-Based Point-of-Care-Testing for Bacterial Infections.
Curr Clin Microbiol Rep. 2024;11(4):241-258. doi: 10.1007/s40588-024-00236-7. Epub 2024 Oct 15.
10
A genome-based survey of invasive pneumococci in Norway over four decades reveals lineage-specific responses to vaccination.
Genome Med. 2024 Oct 25;16(1):123. doi: 10.1186/s13073-024-01396-3.
本文引用的文献
1
Evolution of MRSA during hospital transmission and intercontinental spread.
Science. 2010 Jan 22;327(5964):469-74. doi: 10.1126/science.1182395.
2
What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?
J R Soc Interface. 2010 Jun 6;7(47):905-19. doi: 10.1098/rsif.2009.0400. Epub 2009 Nov 25.
3
Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates.
Lancet. 2009 Sep 12;374(9693):893-902. doi: 10.1016/S0140-6736(09)61204-6.
4
Emergence of a multidrug-resistant clone (ST320) among invasive serotype 19A pneumococci in Spain.
J Antimicrob Chemother. 2009 Sep;64(3):507-10. doi: 10.1093/jac/dkp210. Epub 2009 Jun 17.
5
Hyper-recombination, diversity, and antibiotic resistance in pneumococcus.
Science. 2009 Jun 12;324(5933):1454-7. doi: 10.1126/science.1171908.
6
Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81.
J Bacteriol. 2009 Mar;191(5):1480-9. doi: 10.1128/JB.01343-08. Epub 2008 Dec 29.
7
Impact of conjugate pneumococcal vaccines on antibiotic resistance.
Lancet Infect Dis. 2008 Dec;8(12):785-95. doi: 10.1016/S1473-3099(08)70281-0.
8
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi.
Nat Genet. 2008 Aug;40(8):987-93. doi: 10.1038/ng.195. Epub 2008 Jul 27.
9
Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge.
J Infect Dis. 2008 Aug 1;198(3):375-83. doi: 10.1086/589775.
10
Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005.
J Infect Dis. 2008 Apr 1;197(7):1016-27. doi: 10.1086/528996.
Zotero 插件