Ⅱ期和Ⅲ期浆液性交界性卵巢肿瘤患者中微乳头模式的预后和预后因素。
Prognosis and prognostic factors of the micropapillary pattern in patients treated for stage II and III serous borderline tumors of the ovary.
机构信息
Department of Gynecologic Surgery, University Paris Sud, Institut Gustave Roussy, Villejuif, France.
出版信息
Oncologist. 2011;16(2):189-96. doi: 10.1634/theoncologist.2009-0139. Epub 2011 Jan 27.
Abstract
BACKGROUND
To determine the prognosis of a micropapillary (MP) pattern in patients with stage II and stage III serous borderline tumor of the ovary (SBOT).
METHODS
Review of patients with stage II and stage III SBOT treated or referred to our institution with characterization of an MP pattern and its clinical impact.
RESULTS
In 1969-2006, 168 patients were reviewed. Fifty-six patients had SBOT-MP. The rate of conservative surgery was lower in the SBOT-MP group than in the typical SBOT group, but the rate of patients with more than three peritoneal sites with implants was higher in the SBOT-MP group. The rate of invasive implants was not statistically different between the two groups. Eighteen recurrences were observed (six of them in the form of invasive disease) in the SBOT-MP group. Only one death was observed. The overall survival times and recurrence-free intervals were similar in both groups. The only prognostic factor for recurrence in the SBOT-MP group was the use of conservative surgery.
CONCLUSIONS
In the present series, an MP pattern doesn't appear to signify a poor prognosis. The only prognostic factor for recurrence in SBOT-MP was the use of conservative surgery. Further studies on the MP pattern are needed to evaluate prognosis and the results of conservative surgery.
摘要
背景
为了确定卵巢 II 期和 III 期浆液性交界性肿瘤（SBOT）中微乳头（MP）模式患者的预后。
方法
回顾性分析了在我院接受治疗或转诊的具有 MP 模式特征及其临床影响的 II 期和 III 期 SBOT 患者。
结果
1969 年至 2006 年，共对 168 例患者进行了回顾性分析。56 例患者有 SBOT-MP。与典型 SBOT 组相比，SBOT-MP 组行保守性手术的比例较低，但 SBOT-MP 组有更多的腹膜种植部位（超过三个）的患者比例较高。两组侵袭性种植的发生率无统计学差异。在 SBOT-MP 组中观察到 18 例复发（其中 6 例为侵袭性疾病）。仅观察到 1 例死亡。两组患者的总生存时间和无复发生存期相似。SBOT-MP 组复发的唯一预后因素是采用保守性手术。
结论
在本研究中，MP 模式似乎并不预示着不良预后。SBOT-MP 患者复发的唯一预后因素是采用保守性手术。需要进一步研究 MP 模式以评估其预后和保守性手术的结果。
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