Tamura Shuzo, Oshima Takashi, Yoshihara Kazue, Kanazawa Amane, Yamada Takanobu, Inagaki Daisuke, Sato Tsutomu, Yamamoto Naoto, Shiozawa Manabu, Morinaga Soichiro, Akaike Makoto, Kunisaki Chikara, Tanaka Katsuaki, Masuda Munetaka, Imada Toshio
Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
Anticancer Res. 2011 Jan;31(1):325-9.
Recent studies suggest that altered patterns of stanniocalcin 1 (STC1) gene expression have a role in human carcinogenesis. This study examined the relationship between the relative expression of the STC1 gene and clinicopathological factors in patients with colorectal cancer.
Surgical specimens of cancer tissue and adjacent normal mucosa were obtained from 202 patients with colorectal carcinomas. The relative expression levels of STC1 mRNA in the cancer and the normal adjacent mucosa were measured by quantitative real-time, reverse-transcriptase polymerase chain reaction.
The relative expression levels of the STC1 gene were higher in the cancer tissue than in the normal adjacent mucosa and high expression of STC1 correlated with poor postoperative survival.
High expression of the STC1 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer.
近期研究表明，1,25-二羟基维生素D3-24-羟化酶（STC1）基因表达模式的改变在人类致癌过程中起作用。本研究探讨了STC1基因相对表达与结直肠癌患者临床病理因素之间的关系。
从202例结直肠癌患者中获取癌组织及相邻正常黏膜的手术标本。通过定量实时逆转录聚合酶链反应测量癌组织及相邻正常黏膜中STC1 mRNA的相对表达水平。
癌组织中STC1基因的相对表达水平高于相邻正常黏膜，且STC1高表达与术后生存率低相关。
STC1基因高表达可能是结直肠癌患者术后预后不良的有用预测指标。
