Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland.
Pharmacol Rep. 2010 Nov-Dec;62(6):1225-30. doi: 10.1016/s1734-1140(10)70386-8.
The objective of this study was to determine the degree and specificity of noradrenergic lesions in different areas of the rat brain after intracerebroventricular administration of low doses of 6-hydroxydopamine (6-OHDA) into both lateral ventricles. Our interest focused on the induction of an effective hypothalamic lesion. The results suggest that small doses of 6-OHDA (25 or 50 μg per ventricle) could effectively damage the noradrenergic system in the hypothalamus without significant interfering with the dopamine level and with only a modest reduction in the serotonin concentration.
本研究的目的是确定在双侧侧脑室给予低剂量 6-羟多巴胺（6-OHDA）后，不同脑区去甲肾上腺素能神经元损伤的程度和特异性。我们的兴趣集中在诱导有效的下丘脑损伤上。结果表明，小剂量的 6-OHDA（每脑室 25 或 50μg）可有效损伤下丘脑的去甲肾上腺素能系统，而对多巴胺水平影响不大，仅使 5-羟色胺浓度略有降低。
