Division of Newborn Medicine, Baystate Children's Hospital, Springfield, MA 01199, USA.
J Perinatol. 2011 Mar;31(3):176-82. doi: 10.1038/jp.2010.145. Epub 2011 Jan 27.
To determine association of anemia and red blood cell (RBC) transfusions with necrotizing enterocolitis (NEC) in preterm infants.
A total of 111 preterm infants with NEC ≥ stage 2a were compared with 222 matched controls. In all, 28 clinical variables, including hematocrit (Hct) and RBC transfusions were recorded. Propensity scores and multivariate logistic regression models were created to examine effects on the risk of NEC.
Controlling for other factors, lower Hct was associated with increased odds of NEC (odds ratio (OR)=1.10, P=0.01). RBC transfusion has a temporal relationship with NEC onset. Transfusion within 24 h (OR=7.60, P=0.001) and 48 h (OR=5.55, P=0.001) has a higher odds of developing NEC but this association is not significant by 96 h (OR=2.13, P=0.07), post-transfusion.
Anemia may increase the risk of developing NEC in preterm infants. RBC transfusions are temporally related to NEC. Prospective studies are needed to better evaluate the potential influence of transfusions on the development of NEC.
确定贫血和红细胞（RBC）输血与早产儿坏死性小肠结肠炎（NEC）的关系。
共有 111 例 NEC≥2a 期的早产儿与 222 例匹配对照进行比较。共记录了 28 个临床变量，包括血细胞比容（Hct）和 RBC 输血。采用倾向评分和多变量逻辑回归模型来检查这些因素对 NEC 风险的影响。
在控制其他因素的情况下，较低的 Hct 与 NEC 的发生几率增加相关（比值比（OR）=1.10，P=0.01）。RBC 输血与 NEC 的发病时间有关。输血在 24 小时内（OR=7.60，P=0.001）和 48 小时内（OR=5.55，P=0.001）的发生几率更高，但在 96 小时后（OR=2.13，P=0.07）则不显著。
贫血可能会增加早产儿患 NEC 的风险。RBC 输血与 NEC 有时间关系。需要前瞻性研究来更好地评估输血对 NEC 发展的潜在影响。
