Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Obesity (Silver Spring). 2011 Oct;19(10):2053-62. doi: 10.1038/oby.2010.346. Epub 2011 Jan 27.
Adiponectin is an adipose-secreted protein with influence on several physiologic pathways including those related to insulin sensitivity, inflammation, and atherogenesis. Adiponectin levels are highly heritable and several single-nucleotide polymorphisms (SNPs) in adiponectin-related genes (ADIPOQ, ADIPOR1, ADIPOR2) have been examined in relation to circulating adiponectin levels and obesity phenotypes, but despite differences in adiponectin levels and obesity prevalence by race, few studies have included black participants. Using cross-sectional interview data and blood samples collected from 990 black and 977 white women enrolled in the Southern Community Cohort Study (SCCS) from 2002 to 2006, we examined 25 SNPs in ADIPOQ, 19 in ADIPOR1, and 27 in ADIPOR2 in relation to serum adiponectin levels and BMI using race-stratified linear regression models adjusted for age and percentage African ancestry. SNP rs17366568 in ADIPOQ was significantly associated with serum adiponectin levels in white women only (adjusted mean adiponectin levels = 15.9 for G/G genotype, 13.7 for A/G, and 9.3 for A/A, P = 0.00036). No other SNPs were associated with adiponectin or BMI among blacks or whites. Because adiponectin levels as well as obesity are highly heritable and vary by race but associations with polymorphisms in the ADIPOQ, ADIPOR1, and ADIPOR2 genes have been few in this and other studies, future work including large populations from diverse racial groups is needed to detect additional genetic variants that influence adiponectin and BMI.
脂联素是一种脂肪分泌的蛋白质，对多种生理途径有影响，包括与胰岛素敏感性、炎症和动脉粥样硬化形成相关的途径。脂联素水平具有高度遗传性，在脂联素相关基因（ADIPOQ、ADIPOR1、ADIPOR2）中已经检测到几个单核苷酸多态性（SNP）与循环脂联素水平和肥胖表型有关，但尽管种族之间的脂联素水平和肥胖患病率存在差异，很少有研究包括黑人参与者。使用 2002 年至 2006 年期间参加南方社区队列研究（SCCS）的 990 名黑人女性和 977 名白人女性的横断面访谈数据和血液样本，我们在种族分层的线性回归模型中检查了 ADIPOQ 中的 25 个 SNP、ADIPOR1 中的 19 个 SNP 和 ADIPOR2 中的 27 个 SNP，以研究血清脂联素水平与 BMI 的关系，该模型调整了年龄和非洲裔血统百分比。ADIPOQ 中的 SNP rs17366568 仅与白人女性的血清脂联素水平显著相关（G/G 基因型的平均脂联素水平为 15.9，A/G 为 13.7，A/A 为 9.3，P=0.00036）。在黑人和白人中，没有其他 SNP 与脂联素或 BMI 相关。由于脂联素水平以及肥胖具有高度遗传性，并且因种族而异，但 ADIPOQ、ADIPOR1 和 ADIPOR2 基因中的多态性与这些表型的相关性在本研究和其他研究中很少见，因此需要包括来自不同种族群体的大型人群的未来研究来检测影响脂联素和 BMI 的其他遗传变异。
