Meyer R M
Can Fam Physician. 1985 Jun;31:1231-7.
The features of multiple myeloma are due to plasma cell proliferation and the production of a monoclonal antibody. Skeletal disease with hypercalcemia, bone marrow dysfunction, sepsis, and renal failure are the commonest problems noted. The diagnosis is suggested by the demonstration of monoclonal gammopathy in the serum or the presence of free immunoglobulin light chains in the urine. Other diagnostic features are bone marrow plasmacytosis, hypogammaglobulinemia and lytic bone lesions. Beneficial responses are seen with supportive care of complications, radiotherapy for severe bone disease and chemotherapy to decrease the tumor burden.
多发性骨髓瘤的特征是由于浆细胞增殖和单克隆抗体的产生。高钙血症、骨髓功能障碍、败血症和肾衰竭等骨骼疾病是最常见的问题。血清中出现单克隆丙种球蛋白病或尿中存在游离免疫球蛋白轻链提示诊断。其他诊断特征包括骨髓浆细胞增多、低丙种球蛋白血症和溶骨性骨病变。对并发症进行支持治疗、对严重骨病进行放疗以及进行化疗以减轻肿瘤负担可取得有益的疗效。
