Ichimaru M, Ishimaru T, Mikami M, Matsunaga M
J Natl Cancer Inst. 1982 Aug;69(2):323-8.
The relationship between atomic bomb exposure and the incidence of multiple myeloma has been examined in a fixed cohort of atomic bomb survivors and controls in the life-span study sample for Hiroshima and Nagasaki. From October 1950 to December 1976, 29 cases of multiple myeloma were confirmed in this sample. Our analysis shows that the standardized relative risk (RR) adjusted for city, sex, and age at the time of bombings (ATB) increased with marrow-absorbed radiation dose. The increased RR does not appear to differ between cities or sexes and is demonstrable only for those survivors whose age ATB was between 20 and 59 years. The estimated risk in these individuals is approximately 0.48 cases/million person-years/rad for bone marrow total dose. This excess risk did not become apparent in individuals receiving 50 rad or more in marrow total dose until 20 years or more after exposure.
在广岛和长崎寿命研究样本中的原子弹幸存者及对照的固定队列中，研究了原子弹暴露与多发性骨髓瘤发病率之间的关系。1950年10月至1976年12月期间，该样本中确诊了29例多发性骨髓瘤。我们的分析表明，针对轰炸时的城市、性别和年龄进行调整后的标准化相对风险（RR）随骨髓吸收辐射剂量增加。RR的增加在城市或性别之间似乎没有差异，并且仅在轰炸时年龄在20至59岁之间的那些幸存者中可显现。这些个体的估计风险约为每百万人年每拉德0.48例骨髓总剂量。直到暴露后20年或更长时间，骨髓总剂量接受50拉德或更多的个体中，这种额外风险才变得明显。
