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[正常及人工修饰条件下抗肿瘤药物的致突变活性]

[Mutagenic activity of antineoplastic agents under conditions of normal and artificial modification].

作者信息

Semenov V V

出版信息

Genetika. 1990 Nov;26(11):2020-7.

PMID:2127408
Abstract

Mutagenic effect of vincristine, vinblastine, thiophosphamide, sarcolysine and the supermutagen ethyleneimine was studied in Crepis capillaris germinating seeds at the G phase. Metabolic conditions, prolongation of cell cycle, specific activity of preparation as well as inhibition of DNA synthesis were found to modify the mutagenic process induced by antitumour agents.

摘要

研究了长春新碱、长春碱、硫代磷酰胺、溶肉瘤素和超诱变剂乙烯亚胺对处于G期的碎米荠萌发种子的诱变作用。发现代谢条件、细胞周期延长、制剂的比活性以及DNA合成的抑制会改变抗肿瘤药物诱导的诱变过程。

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