Shcheglova E G, Chebotarev A N
Biull Eksp Biol Med. 1983 Nov;96(11):93-5.
Dose dependencies of the induction of sister chromatid exchanges (SCEs) and chromosome aberrations were studied under in vivo exposure of mouse bone marrow cells to 5 alkylating agents. The efficacy of the induction of SCEs for all the substances was 20 to 60 times higher than that of the induction of chromosome aberrations. It was demonstrated that SCEs induced by chemical mutagens in vivo and in vitro are more sensitive tests than chromosome aberrations.
在小鼠骨髓细胞体内暴露于5种烷化剂的情况下，研究了姐妹染色单体交换（SCEs）诱导和染色体畸变的剂量依赖性。所有物质诱导SCEs的效力比诱导染色体畸变的效力高20至60倍。结果表明，化学诱变剂在体内和体外诱导的SCEs比染色体畸变是更敏感的检测方法。
