NMR 证据表明，NIS 促进的 1-苯基-4-戊烯基胺的环化反应的动力学和热力学产物。反式-2-苯基-5-碘代哌啶的合成和反应性。

NMR evidence of the kinetic and thermodynamic products in the NIS promoted cyclization of 1-phenyl-4-pentenylamines. Synthesis and reactivity of trans-2-phenyl-5-iodopiperidines.

机构信息

Laboratori de Química Orgànica, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain.

出版信息

Chem Commun (Camb). 2011 Mar 21;47(11):3251-3. doi: 10.1039/c0cc05105e. Epub 2011 Jan 28.

DOI:10.1039/c0cc05105e

PMID:21274472

Abstract

The intramolecular reaction of secondary amines with tethered alkenes using NIS was studied, which gave insight into the kinetic vs. thermodynamic control of the iodoaminocyclization and the regioselectivity of the aziridinium ring-opening reactions, and led to functionalized piperidines.

摘要

本文研究了二级胺与连接的烯烃在 NIS 作用下的分子内反应，深入了解了碘代氨基环化的动力学与热力学控制以及氮丙啶环开环反应的区域选择性，并得到了官能化的哌啶。