Foguet Q, Alvárez M J, Castells E, Arrufat F
Consorcio Hospitalario de Vic, Catalunya, España.
Actas Esp Psiquiatr. 2011 Jan-Feb;39(1):75-8. Epub 2011 Jan 1.
The symptom of depersonalization is frequently associated with other mental disorders, physiological effects of substances or medical diseases. However, it is rare that, as in the case presented, the experiences of depersonalization form an isolated entity, a primary depersonalization disorder. Among the many psychoactive drugs studied, none of them has been shown to be the treatment of choice. Among those with which the best results are obtained are opioid receptor antagonists (naloxone and naltrexone), the combination of selective serotonin reuptake inhibitors with lamotrigine and clorimipramine. Although with virtually no evidence, we are presenting a case that responded spectacularly to methylphenidate.
人格解体症状常与其他精神障碍、物质的生理效应或医学疾病相关。然而，如所呈现的案例那样，人格解体体验形成一个孤立实体，即原发性人格解体障碍的情况却很罕见。在众多研究过的精神活性药物中，没有一种被证明是首选治疗药物。取得最佳效果的药物有阿片受体拮抗剂（纳洛酮和纳曲酮）、选择性5-羟色胺再摄取抑制剂与拉莫三嗪及氯米帕明的联合使用。尽管几乎没有证据，但我们在此呈现一个对哌甲酯反应极佳的病例。
