Fachbereich Organische Chemie, TU-Kaiserslautern, Kaiserslautern, Germany.
Chemistry. 2011 Feb 25;17(9):2689-97. doi: 10.1002/chem.201002749. Epub 2011 Jan 27.
Potassium (trifluoromethyl)trimethoxyborate is introduced as a new source of CF(3) nucleophiles in copper-catalyzed trifluoromethylation reactions. The crystalline salt is stable on storage, easy to handle, and can be obtained in near-quantitative yields simply by mixing B(OMe)(3), CF(3)SiMe(3), and KF. The trifluoromethylation reagent allows the conversion of various aryl iodides into the corresponding benzotrifluorides in high yields under mild, base-free conditions in the presence of catalytic quantities of a Cu(I)/1,10-phenanthroline complex.
三氟甲基三氟甲氧基硼酸钾被引入到铜催化的三氟甲基化反应中，作为一种新的 CF3 亲核试剂来源。这种晶体盐在储存时稳定，易于处理，只需将 B(OMe)3、CF3SiMe3 和 KF 混合即可近乎定量地获得。在催化量的 Cu(I)/1,10-菲咯啉配合物存在下，该三氟甲基化试剂在温和、无碱条件下，可将各种芳基碘转化为相应的苯并三氟化物，产率很高。
