Zhu Cheng-Liang, Zhang Yong-Qiang, Yuan Yong-An, Xu Hao
Department of Chemistry, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA 30303, USA.
Synlett. 2015;26(3):345-349. doi: 10.1055/s-0034-1379319.
Direct C-H trifluoromethylation of heterocycles is a valuable transformation. In particular, nonprecious metal-catalyzed C-H trifluoromethylation processes, which do not proceed through CF radical species, have been less developed. In this cluster report, a new copper-catalyzed aerobic C-H trifluoromethylation of phenanthrolines is described. This transformation affords trifluoromethylated phenanthrolines that have not been synthesized and preliminary mechanistic studies suggest that the CF group transfer may occur through cooperative activation.
杂环的直接C-H三氟甲基化是一种有价值的转化反应。特别是，不通过CF自由基物种进行的非贵金属催化的C-H三氟甲基化过程开发较少。在本专题报告中，描述了一种新的铜催化菲咯啉的需氧C-H三氟甲基化反应。该转化反应可得到尚未合成的三氟甲基化菲咯啉，初步机理研究表明CF基团转移可能通过协同活化发生。
