Department of Pharmacy Practice, Raabe College of Pharmacy, Ohio Northern University, Ada, Ohio, USA.
Pharmacotherapy. 2011 Feb;31(2):115-27. doi: 10.1592/phco.31.2.115.
Clinical pharmacists must often interpret and use data derived from observational studies when making clinical decisions and recommendations, answering drug information questions, and educating patients about drug therapy. This is the third article in a three-part series intended to enhance clinical pharmacists' understanding of methods frequently used in such research and their application to patient care. Principles for critical evaluation of published observational studies are presented. Issues of bias and confounding that must be taken into account when assessing the data derived from observational studies are explained. Finally, examples of applications in pharmacy practice are presented.
临床药师在做出临床决策和建议、回答药物信息问题以及向患者提供药物治疗教育时，经常需要解释和使用来自观察性研究的数据。这是三篇系列文章中的第三篇，旨在提高临床药师对这类研究中常用方法的理解及其在患者护理中的应用。本文介绍了评价已发表观察性研究的原则，解释了在评估来自观察性研究的数据时必须考虑的偏倚和混杂因素问题，最后还介绍了在药学实践中的应用实例。
