University of Minnesota, Center for Immunology, Minneapolis, Minnesota, USA.
Ann N Y Acad Sci. 2011 Jan;1217:18-31. doi: 10.1111/j.1749-6632.2010.05907.x.
The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated by a number of cytokine and growth hormone receptors and plays a key role in the development and function of many organ systems. In this review, we focus on recent discoveries about the role of STAT5 in the development and function of B and T lymphocytes. Of particular interest is the growing appreciation for the function of STAT5 as a transcriptional repressor. Finally, we discuss recent discoveries about the role of STAT5 in transformation of B and T lymphocytes.
转录因子信号转导子和转录激活子 5（STAT5）被许多细胞因子和生长激素受体激活，在许多器官系统的发育和功能中发挥关键作用。在这篇综述中，我们重点介绍了 STAT5 在 B 和 T 淋巴细胞发育和功能中的作用的最新发现。特别有趣的是，STAT5 作为转录抑制剂的功能日益受到重视。最后，我们讨论了 STAT5 在 B 和 T 淋巴细胞转化中的作用的最新发现。
