Department of Pediatric Hematology and Oncology, Shenzhen Children's Hospital, China Medical University, Shenzhen, Guangdong 518000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Aug 15;24(8):942-947. doi: 10.7499/j.issn.1008-8830.2203117.
Signal transducer and activator of transcription 5 (STAT5) can be involved in the processes such as cell proliferation, differentiation, apoptosis, and hematopoiesis, and its dysregulation is closely associated with the development and progression of malignant tumors including leukemia and may affect the treatment outcome and prognosis of pediatric patients. Identification of STAT5 can facilitate targeted therapy to improve the response rate of children with acute lymphoblastic leukemia. This article reviews the impact of STAT5 on the development/progression, targeted therapy strategies and the prognosis of childhood acute lymphoblastic leukemia.
信号转导子和转录激活子 5（STAT5）可参与细胞增殖、分化、凋亡和造血等过程，其失调与包括白血病在内的恶性肿瘤的发生和发展密切相关，并可能影响儿科患者的治疗效果和预后。STAT5 的鉴定有助于靶向治疗，以提高儿童急性淋巴细胞白血病的反应率。本文综述了 STAT5 对儿童急性淋巴细胞白血病的发展/进展、靶向治疗策略和预后的影响。
