TLR2 依赖性炎症在转移进展中的作用。
Role of TLR2-dependent inflammation in metastatic progression.
机构信息
Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, La Jolla, California, USA.
出版信息
Ann N Y Acad Sci. 2011 Jan;1217:191-206. doi: 10.1111/j.1749-6632.2010.05882.x.
Abstract
Inflammation is a part of the host defense system, which provides protection against invading pathogens. However, it has become increasingly clear that inflammation can be evoked by endogenous mediators through Toll-like receptors (TLRs) to enhance tumor progression and metastasis. Here, we discuss the roles of TLR-mediated inflammation in tumor progression and the mechanisms through which it accomplishes this pathogenic function.
摘要
炎症是宿主防御系统的一部分，它提供了对抗入侵病原体的保护。然而，越来越明显的是，炎症可以通过 Toll 样受体 (TLR) 被内源性介质所激发，从而促进肿瘤的进展和转移。在这里，我们讨论了 TLR 介导的炎症在肿瘤进展中的作用以及它完成这种致病功能的机制。
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