健康人妊娠过程中外周血 CD160+ 淋巴细胞的表达谱。
Expression profiles of peripheral CD160+ lymphocytes during the course of healthy human pregnancy.
机构信息
Department of Medical Microbiology and Immunology, Medical School, University of Pecs, Szigeti ut 12, Pecs, Hungary.
出版信息
Am J Reprod Immunol. 2011 Aug;66(2):137-42. doi: 10.1111/j.1600-0897.2011.00983.x. Epub 2011 Jan 31.
PROBLEM
CD160 receptor is expressed by natural killer (NK) and T-cell subsets, and after activation, it could enhance cytotoxicity or pro-inflammatory cytokine production on NK cells. Here, we investigated the phenotype of peripheral CD160+ cells during healthy pregnancy.
METHOD OF STUDY
We analyzed the expression of CD69 activation marker, gamma/delta TCR, and NKG2A or NKG2D NK cell receptors on CD160+ lymphocytes of non-pregnant and healthy pregnant women at four different stages of pregnancy by flow cytometry.
RESULTS
In our hands, CD160 receptor-positive lymphocytes were present during pregnancy; however, they had different characteristics depending on gestational age. During implantation, CD160+ cells showed low activation rate, decreased NK receptor expression while 40% of Vδ2 + T cells expressed CD160 receptor. In turn, all the above parameters increased as pregnancy proceeds.
CONCLUSION
Our results indicate that CD160+ lymphocytes could be able to play a role in the maintenance of healthy pregnancy.
问题
CD160 受体表达于自然杀伤 (NK) 和 T 细胞亚群，激活后，可增强 NK 细胞的细胞毒性或促炎细胞因子的产生。在此，我们研究了健康妊娠期间外周血 CD160+细胞的表型。
研究方法
我们通过流式细胞术分析了非妊娠和健康孕妇在妊娠四个不同阶段外周血 CD160+淋巴细胞上 CD69 激活标志物、γ/δ TCR 和 NKG2A 或 NKG2D NK 细胞受体的表达。
结果
在我们的研究中，妊娠期间存在 CD160 受体阳性淋巴细胞，但它们的特征因孕龄而异。在着床期，CD160+细胞激活率低，NK 受体表达减少，而 40%的 Vδ2+T 细胞表达 CD160 受体。相反，随着妊娠的进展，所有上述参数均增加。
结论
我们的结果表明，CD160+淋巴细胞可能在维持健康妊娠中发挥作用。
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