Department of Biomedicine, University of Bergen, Bergen, Norway.
Genes Brain Behav. 2011 Jun;10(4):418-23. doi: 10.1111/j.1601-183X.2011.00680.x. Epub 2011 Feb 18.
Attention-deficit/hyperactivity disorder (ADHD) has an estimated prevalence of 3-5% in adults. Genome-wide association (GWA) studies have not been performed in adults with ADHD and studies in children have so far been inconclusive, possibly because of the small sample sizes. Larger GWA studies have been performed on bipolar disorder (BD) and BD symptoms, and several potential risk genes have been reported. ADHD and BD share many clinical features and comorbidity between these two disorders is common. We therefore wanted to examine whether the reported BD genetic variants in CACNA1C, ANK3, MYO5B, TSPAN8 and ZNF804A loci are associated with ADHD or with scores on the Mood Disorder Questionnaire (MDQ), a commonly used screening instrument for bipolar spectrum disorders. We studied 561 adult Norwegian ADHD patients and 711 controls from the general population. No significant associations or trends were found between any of the single nucleotide polymorphisms (SNPs) studied and ADHD [odds ratios (ORs) ≤ 1.05]. However, a weak association was found between rs1344706 in ZNF804A (OR = 1.25; P = 0.05) and MDQ. In conclusion, it seems unlikely that these six SNPs with strong evidence of association in BD GWA studies are shared risk variants between ADHD and BD.
注意缺陷多动障碍（ADHD）在成年人中的患病率估计为 3-5%。尚未对 ADHD 成年人进行全基因组关联（GWA）研究，而对儿童的研究迄今为止尚无定论，这可能是由于样本量小。已经对双相情感障碍（BD）和 BD 症状进行了更大规模的 GWA 研究，并报告了一些潜在的风险基因。ADHD 和 BD 具有许多共同的临床特征，这两种疾病之间的共病很常见。因此，我们想研究报告的 CACNA1C、ANK3、MYO5B、TSPAN8 和 ZNF804A 基因座中的 BD 遗传变异是否与 ADHD 或 Mood Disorder Questionnaire（MDQ）的评分相关，MDQ 是一种常用于双相谱系障碍的筛查工具。我们研究了 561 名挪威成年 ADHD 患者和 711 名来自普通人群的对照者。在所研究的任何单核苷酸多态性（SNP）与 ADHD 之间均未发现显著的关联或趋势[比值比（ORs）≤1.05]。然而，在 ZNF804A 中的 rs1344706 与 MDQ 之间发现了微弱的关联（OR=1.25；P=0.05）。总之，这些在 BD GWA 研究中具有强烈关联证据的六个 SNP 不太可能是 ADHD 和 BD 之间的共同风险变异。
