Programme National Contre la Tuberculose, Cotonou, Benin.
Int J Tuberc Lung Dis. 2011 Jan;15(1):67-70.
The main tuberculosis (TB) centre in Benin, West Africa, where only 2% of adult pulmonary TB cases are sputum smear-negative, all other pulmonary cases being smear-positive.
To assess the burden of smear-negative, culture-positive pulmonary TB among TB suspects in Cotonou, and to estimate the total number of non-smear-positive TB cases at country level.
For 1 year, one morning sputum culture was performed for every TB suspect (cough lasting >3 weeks, as defined in Benin's national guidelines) with three negative sputum smears (fluorescence technique).
Of 214 TB suspects for whom culture was performed, only 22 smear-negative, culture-positive cases were identified. During the same period, 831 sputum smear-positive cases were diagnosed. Culture therefore contributed only 2.6% of the total number of bacteriologically proven cases.
These results show the relatively low input of culture in TB diagnosis among chronic coughers in Cotonou, Benin, and demonstrates that the expected number of non-smear-positive TB cases in Benin is probably much lower than the World Health Organization's current annual estimates.
贝宁西部的主要结核病（TB）中心，只有 2%的成人肺结核病例为痰涂片阴性，所有其他肺结核病例均为痰涂片阳性。
评估科托努疑似结核病患者中痰涂片阴性、培养阳性肺结核的负担，并估计全国非涂片阳性结核病病例的总数。
在 1 年期间，对所有（按照贝宁国家指南定义，咳嗽持续 >3 周）符合条件的结核疑似患者（连续三次痰涂片阴性（荧光技术））进行一次晨间痰培养。
在接受培养的 214 例结核疑似患者中，仅发现 22 例痰涂片阴性、培养阳性的病例。在此期间，共诊断出 831 例痰涂片阳性病例。因此，培养仅占细菌学确诊病例总数的 2.6%。
这些结果表明，在贝宁科托努的慢性咳嗽患者中，培养在结核病诊断中的作用相对较低，表明贝宁预期的非涂片阳性结核病病例数量可能远低于世界卫生组织目前的年度估计数。
