Department of Health Professions, Manchester Metropolitan University, Manchester, UK.
Respir Care. 2011 May;56(5):644-52. doi: 10.4187/respcare.01002. Epub 2011 Jan 27.
Anemia is common in patients with chronic diseases. However, little is known regarding the prevalence of comorbid anemia and its impact on quality of life, healthcare utilization, and mortality in patients with COPD. We conducted a systematic review and synthesis of the literature (1966 to March 2010). The prevalence of comorbid anemia in patients with COPD ranges from 7.5% to 34%, depending upon the populations selected and diagnostic tools employed to determine the level of hemoglobin. Comorbid anemia in patients with COPD was associated with greater healthcare resource utilization, impaired quality of life, older age, and male gender. Moreover, anemia in patients with COPD is an independent prognostic predictor of premature mortality and a greater likelihood of hospitalization. The true prevalence of anemia in patients with COPD is unknown. There is a lack of consensus agreement regarding this hematological abnormality's true frequency. Based on the findings from the existing literature, more work is necessary to establish the true prevalence of anemia in COPD. Robust and prospective clinical studies are needed to improve the management of COPD patients with comorbid anemia.
贫血在慢性病患者中很常见。然而，对于合并贫血的患病率及其对慢性阻塞性肺疾病（COPD）患者的生活质量、医疗保健利用和死亡率的影响，我们知之甚少。我们进行了系统的文献综述和综合分析（1966 年至 2010 年 3 月）。根据所选择的人群和用于确定血红蛋白水平的诊断工具，COPD 患者合并贫血的患病率从 7.5%到 34%不等。COPD 合并贫血的患者与更多的医疗保健资源利用、生活质量受损、年龄较大和男性有关。此外，COPD 患者的贫血是过早死亡和住院可能性增加的独立预后预测因子。COPD 患者贫血的真实患病率尚不清楚。对于这种血液学异常的真实频率缺乏共识。基于现有文献的研究结果，需要开展更多的工作来确定 COPD 患者贫血的真实患病率。需要进行强有力的前瞻性临床研究来改善合并贫血的 COPD 患者的管理。
