Emini E A, Schleif W A, Quintero J C, Conard P G, Eichberg J W, Vlasuk G P, Lehman E D, Polokoff M A, Schaeffer T F, Schultz L D
Merck, Sharp and Dohme Research Laboratories, West Point, PA 19486.
AIDS Res Hum Retroviruses. 1990 Nov;6(11):1247-50. doi: 10.1089/aid.1990.6.1247.
Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 (HIV-1) was used to immunize chimpanzees. The animals developed high titers of antibodies to p55 as well as to the p24 and p17 mature cleavage products of the core precursor. Virus-neutralizing antibodies were not elicited. The induced immune responses did not prevent establishment of HIV-1 infection following challenge of one immunized chimpanzee with live virus.
