• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

动物模型对理解甲型流感病毒的宿主范围和毒力的贡献。

The contribution of animal models to the understanding of the host range and virulence of influenza A viruses.

机构信息

Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA.

出版信息

Microbes Infect. 2011 May;13(5):502-15. doi: 10.1016/j.micinf.2011.01.014. Epub 2011 Jan 27.

DOI:10.1016/j.micinf.2011.01.014
PMID:21276869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3071864/
Abstract

Since ferrets were first used in 1933 during the initial isolation of influenza A viruses, animal models have been critical for influenza research. The following review discusses the contribution of mice, ferrets, and non-human primates to the study of influenza virus host range and pathogenicity.

摘要

自 1933 年首次在流感 A 病毒的初步分离中使用雪貂以来，动物模型一直是流感研究的关键。以下综述讨论了小鼠、雪貂和非人类灵长类动物对流感病毒宿主范围和致病性研究的贡献。

相似文献

1
The contribution of animal models to the understanding of the host range and virulence of influenza A viruses.动物模型对理解甲型流感病毒的宿主范围和毒力的贡献。
Microbes Infect. 2011 May;13(5):502-15. doi: 10.1016/j.micinf.2011.01.014. Epub 2011 Jan 27.
2
Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses.源自大流行（H1N1）2009 流感病毒和流行的甲型流感病毒的聚合酶重配病毒的毒力和遗传相容性。
J Virol. 2011 Jul;85(13):6275-86. doi: 10.1128/JVI.02125-10. Epub 2011 Apr 20.
3
Confronting influenza virus: a common but ever-changing pathogen.对抗流感病毒：一种常见但不断变化的病原体。
Microbes Infect. 2011 May;13(5):468-9. doi: 10.1016/j.micinf.2011.01.011. Epub 2011 Jan 27.
4
An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice.一种早期的“经典”猪源H1N1流感病毒在雪貂和小鼠中表现出与1918年大流行病毒相似的致病性。
Virology. 2009 Oct 25;393(2):338-45. doi: 10.1016/j.virol.2009.08.021. Epub 2009 Sep 5.
5
Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemic.三重重配猪 H1N1 流感病毒在 2009 年 H1N1 大流行前的发病机制和传播。
J Virol. 2011 Feb;85(4):1563-72. doi: 10.1128/JVI.02231-10. Epub 2010 Dec 1.
6
Of ferrets and humans: influenza pathogenesis.关于雪貂和人类：流感发病机制。
J Infect Dis. 2010 Apr 1;201(7):976-7. doi: 10.1086/651133.
7
Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses.毒力 PB1-F2 残基：对 H1N1 流感病毒在小鼠中的适应性的影响及其在人类流感病毒进化过程中的变化。
Sci Rep. 2018 May 10;8(1):7474. doi: 10.1038/s41598-018-25707-y.
8
Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice.雪貂和小鼠中甲型流感病毒（H7N9）的发病机制和传播。
Nature. 2013 Sep 26;501(7468):556-9. doi: 10.1038/nature12391. Epub 2013 Jul 10.
9
Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets.高致病性禽流感H5N6病毒对人源S型唾液酸受体表现出更高的亲和力，并在雪貂模型中出现接触传播。
J Virol. 2016 Jun 24;90(14):6235-6243. doi: 10.1128/JVI.00127-16. Print 2016 Jul 15.
10
Characterization of H7N9 influenza A viruses isolated from humans.人感染 H7N9 流感病毒的特征。
Nature. 2013 Sep 26;501(7468):551-5. doi: 10.1038/nature12392. Epub 2013 Jul 10.

引用本文的文献

1
Nonhuman primate models of pediatric viral diseases.儿科病毒性疾病的非人灵长类动物模型。
Front Cell Infect Microbiol. 2024 Dec 3;14:1493885. doi: 10.3389/fcimb.2024.1493885. eCollection 2024.
2
Ferrets as a Mammalian Model to Study Influenza Virus-Bacteria Interactions.雪貂作为研究流感病毒与细菌相互作用的哺乳动物模型。
J Infect Dis. 2024 Feb 14;229(2):608-615. doi: 10.1093/infdis/jiad408.
3
Zebrafish-based platform for emerging bio-contaminants and virus inactivation research.基于斑马鱼的新兴生物污染物和病毒灭活研究平台。
Sci Total Environ. 2023 May 10;872:162197. doi: 10.1016/j.scitotenv.2023.162197. Epub 2023 Feb 11.
4
Vaccination with Deglycosylated Modified Hemagglutinin Broadly Protects against Influenza Virus Infection in Mice and Ferrets.用去糖基化修饰血凝素进行疫苗接种可广泛保护小鼠和雪貂免受流感病毒感染。
Vaccines (Basel). 2022 Aug 11;10(8):1304. doi: 10.3390/vaccines10081304.
5
The Emergence and Zoonotic Transmission of H10Nx Avian Influenza Virus Infections.H10Nx 禽流感病毒感染的出现与动物源性传播。
mBio. 2021 Oct 26;12(5):e0178521. doi: 10.1128/mBio.01785-21. Epub 2021 Sep 7.
6
Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2.家养和野生动物来源的高分化气道上皮细胞培养物对严重急性呼吸综合征冠状病毒 2 的易感性。
Emerg Infect Dis. 2021 Jul;27(7):1811-1820. doi: 10.3201/eid2707.204660.
7
Hemagglutinin Stability and Its Impact on Influenza A Virus Infectivity, Pathogenicity, and Transmissibility in Avians, Mice, Swine, Seals, Ferrets, and Humans.血凝素稳定性及其对禽类、小鼠、猪、海豹、雪貂和人类中流感 A 病毒感染力、致病性和传染性的影响。
Viruses. 2021 Apr 24;13(5):746. doi: 10.3390/v13050746.
8
Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine.甲型流感病毒疫苗接种：免疫、保护及通用疫苗的最新进展
Vaccines (Basel). 2020 Aug 3;8(3):434. doi: 10.3390/vaccines8030434.
9
The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses.H6Nx 禽流感病毒的演化、传播及全球威胁
Viruses. 2020 Jun 22;12(6):673. doi: 10.3390/v12060673.
10
Animal models for the risk assessment of viral pandemic potential.用于评估病毒大流行潜力风险的动物模型。
Lab Anim Res. 2020 Apr 22;36:11. doi: 10.1186/s42826-020-00040-6. eCollection 2020.

本文引用的文献

1
The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase.PB2-E627K 突变削弱了含有 2009 年 H1N1 流感大流行聚合酶的病毒。
mBio. 2010 May 18;1(1):e00067-10. doi: 10.1128/mBio.00067-10.
2
Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010.预防和控制流感的疫苗：免疫实践咨询委员会（ACIP）的建议，2010 年。
MMWR Recomm Rep. 2010 Aug 6;59(RR-8):1-62.
3
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.D225G 突变使大流行性流感 H1N1（2009）病毒血凝素的毒力增强。
Exp Biol Med (Maywood). 2010 Aug;235(8):981-8. doi: 10.1258/ebm.2010.010071.
4
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.流感病毒 RNA 聚合酶的 PB2 亚基通过与线粒体抗病毒信号蛋白相互作用并抑制β干扰素的表达来影响毒力。
J Virol. 2010 Sep;84(17):8433-45. doi: 10.1128/JVI.00879-10. Epub 2010 Jun 10.
5
A polymorphism in the hemagglutinin of the human isolate of a highly pathogenic H5N1 influenza virus determines organ tropism in mice.一个高致病性 H5N1 流感病毒的人分离株血凝素中的一个多态性决定了其在小鼠中的器官嗜性。
J Virol. 2010 Aug;84(16):8316-21. doi: 10.1128/JVI.00850-10. Epub 2010 Jun 2.
6
Evaluation of replication and cross-reactive antibody responses of H2 subtype influenza viruses in mice and ferrets.评估 H2 亚型流感病毒在小鼠和雪貂中的复制和交叉反应性抗体反应。
J Virol. 2010 Aug;84(15):7695-702. doi: 10.1128/JVI.00511-10. Epub 2010 May 26.
7
Modeling host responses in ferrets during A/California/07/2009 influenza infection.模拟雪貂感染 A/California/07/2009 流感时的宿主反应。
Virology. 2010 Jun 5;401(2):257-65. doi: 10.1016/j.virol.2010.02.020. Epub 2010 Mar 23.
8
Influenza H1N1 A/Solomon Island/3/06 virus receptor binding specificity correlates with virus pathogenicity, antigenicity, and immunogenicity in ferrets.甲型 H1N1 流感病毒/所罗门群岛/3/06 病毒受体结合特异性与病毒在雪貂中的致病性、抗原性和免疫原性相关。
J Virol. 2010 May;84(10):4936-45. doi: 10.1128/JVI.02489-09. Epub 2010 Mar 3.
9
Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus.雪貂感染新型 H1N1 流感病毒所致肺炎的严重程度介於季节性 H1N1 病毒和高致病性禽流感 H5N1 病毒之间。
J Infect Dis. 2010 Apr 1;201(7):993-9. doi: 10.1086/651132.
10
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.PB2 残基 271 在流感病毒在哺乳动物宿主细胞中增强聚合酶活性方面发挥关键作用。
J Virol. 2010 May;84(9):4395-406. doi: 10.1128/JVI.02642-09. Epub 2010 Feb 24.