Semenzato Martina, Cogliati Sara, Scorrano Luca
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.
Chem Biol. 2011 Jan 28;18(1):8-9. doi: 10.1016/j.chembiol.2011.01.001.
Proapoptotic drugs targeting the mitochondrial Bcl-2 rheostat of apoptosis are tools to selectively kill cancer cells. Sato et al. (2011) expand the available toolkit by identifying the target of the cytotoxic natural product aurilide in the prohibitin Opa1-dependent apoptotic cristae remodeling.
