Prohibitin(g) cancer: aurilide and killing by Opa1-dependent cristae remodeling.
作者信息
Semenzato Martina, Cogliati Sara, Scorrano Luca
机构信息
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.
出版信息
Chem Biol. 2011 Jan 28;18(1):8-9. doi: 10.1016/j.chembiol.2011.01.001.
Abstract
Proapoptotic drugs targeting the mitochondrial Bcl-2 rheostat of apoptosis are tools to selectively kill cancer cells. Sato et al. (2011) expand the available toolkit by identifying the target of the cytotoxic natural product aurilide in the prohibitin Opa1-dependent apoptotic cristae remodeling.
摘要
Zotero 插件