抗增殖蛋白在衰老中的作用及对衰老相关疾病的治疗潜力。
Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases.
作者信息
Belser Misa, Walker David W
机构信息
Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.
出版信息
Front Genet. 2021 Oct 29;12:714228. doi: 10.3389/fgene.2021.714228. eCollection 2021.
A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins (PHB1 and PHB2) assemble at the mitochondrial inner membrane and are critical for mitochondrial homeostasis. In addition, prohibitins (PHBs) have diverse roles in cell and organismal biology. Here, we will discuss the role of PHBs in mitophagy, oxidative phosphorylation, cellular senescence, and apoptosis. We will also discuss the role of PHBs in modulating lifespan. In addition, we will review the links between PHBs and diseases of aging. Finally, we will discuss the emerging concept that PHBs may represent an attractive therapeutic target to counteract aging and age-onset disease.
线粒体功能下降长期以来一直与年龄相关的健康衰退有关。多项证据表明，刺激线粒体自噬（线粒体吞噬）的干预措施可以延缓衰老并延长健康寿命。 prohibitin蛋白（PHB1和PHB2）在线粒体内膜组装，对线粒体稳态至关重要。此外，prohibitin蛋白（PHBs）在细胞和生物体生物学中具有多种作用。在这里，我们将讨论PHBs在线粒体吞噬、氧化磷酸化、细胞衰老和细胞凋亡中的作用。我们还将讨论PHBs在调节寿命方面的作用。此外，我们将综述PHBs与衰老相关疾病之间的联系。最后，我们将讨论一个新出现的概念，即PHBs可能是对抗衰老和老年疾病的一个有吸引力的治疗靶点。
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