Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Acad Radiol. 2011 Apr;18(4):424-36. doi: 10.1016/j.acra.2010.10.020. Epub 2011 Jan 28.
Recent discoveries characterizing the molecular basis of lung cancer brought fundamental changes in lung cancer treatment. The authors review the molecular pathogenesis of lung cancer, including genomic abnormalities, targeted therapies, and resistance mechanisms, and discuss lung cancer imaging with novel techniques. Knowledge of the molecular basis of lung cancer is essential for radiologists to properly interpret imaging and assess response to therapy. Quantitative and functional imaging helps assessing the biologic behavior of lung cancer.
最近对肺癌分子基础的研究发现给肺癌的治疗带来了根本性的变化。作者回顾了肺癌的分子发病机制，包括基因组异常、靶向治疗和耐药机制，并讨论了新技术在肺癌成像中的应用。了解肺癌的分子基础对于放射科医生正确解读影像和评估治疗反应至关重要。定量和功能成像有助于评估肺癌的生物学行为。
