分子医学时代的肺癌影像学
Imaging of lung cancer in the era of molecular medicine.
机构信息
Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
出版信息
Acad Radiol. 2011 Apr;18(4):424-36. doi: 10.1016/j.acra.2010.10.020. Epub 2011 Jan 28.
Abstract
Recent discoveries characterizing the molecular basis of lung cancer brought fundamental changes in lung cancer treatment. The authors review the molecular pathogenesis of lung cancer, including genomic abnormalities, targeted therapies, and resistance mechanisms, and discuss lung cancer imaging with novel techniques. Knowledge of the molecular basis of lung cancer is essential for radiologists to properly interpret imaging and assess response to therapy. Quantitative and functional imaging helps assessing the biologic behavior of lung cancer.
摘要
最近对肺癌分子基础的研究发现给肺癌的治疗带来了根本性的变化。作者回顾了肺癌的分子发病机制，包括基因组异常、靶向治疗和耐药机制，并讨论了新技术在肺癌成像中的应用。了解肺癌的分子基础对于放射科医生正确解读影像和评估治疗反应至关重要。定量和功能成像有助于评估肺癌的生物学行为。
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1
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2
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Eur Radiol. 2010 Dec;20(12):2890-8. doi: 10.1007/s00330-010-1869-5. Epub 2010 Jul 13.
3
Usefulness of dynamic contrast enhanced computed tomography in patients with non-small-cell lung cancer scheduled for radiation therapy.动态对比增强 CT 在计划接受放疗的非小细胞肺癌患者中的应用。
Lung Cancer. 2010 Dec;70(3):280-5. doi: 10.1016/j.lungcan.2010.03.004. Epub 2010 Apr 3.
4
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J Clin Oncol. 2010 Jan 10;28(2):357-60. doi: 10.1200/JCO.2009.24.7049. Epub 2009 Nov 30.
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