Departments of Physiology and Pediatrics, Perinatal Research Facility, University of Colorado School of Medicine, 13243 East 23rd Avenue, Mail Stop F441, Aurora, CO 80045, USA.
Clin Chest Med. 2011 Mar;32(1):15-19. doi: 10.1016/j.ccm.2010.11.007.
In the past 20 years, measurements of umbilical blood flow and umbilical venous PO2, oxygen saturation, pH, and oxygen capacity have provided reliable information about the state of oxygenation of normal and growth restricted human fetuses. However, no comparable information is available about the uterine circulation. Therefore, understanding of oxygen transport across the human placenta and the effect of maternal ventilation on fetal oxygenation is tentative, and currently based on a model that is derived from evidence in another species. The main purpose of this model is to illustrate the kind of information that is needed to make further progress in this area.
在过去的 20 年中,对脐血流和脐静脉 PO2、氧饱和度、pH 值和氧容量的测量为了解正常和生长受限的胎儿的氧合状态提供了可靠的信息。然而,关于子宫循环却没有类似的信息。因此,对于氧在人类胎盘内的转运以及母体通气对胎儿氧合的影响的理解是不确定的,目前还基于从另一种物种获得的证据的模型。该模型的主要目的是说明在这一领域取得进一步进展所需的信息类型。