College of Pharmacy and Medical Research Center, Chungbuk National University, 12 Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.
Pharmacol Ther. 2011 May;130(2):157-76. doi: 10.1016/j.pharmthera.2011.01.010. Epub 2011 Jan 26.
The bark and/or seed cones of the Magnolia tree have been used in traditional herbal medicines in Korea, China and Japan. Bioactive ingredients such as magnolol, honokiol, 4-O-methylhonokiol and obovatol have received great attention, judging by the large number of investigators who have studied their pharmacological effects for the treatment of various diseases. Recently, many investigators reported the anti-cancer, anti-stress, anti-anxiety, anti-depressant, anti-oxidant, anti-inflammatory and hepatoprotective effects as well as toxicities and pharmacokinetics data, however, the mechanisms underlying these pharmacological activities are not clear. The aim of this study was to review a variety of experimental and clinical reports and, describe the effectiveness, toxicities and pharmacokinetics, and possible mechanisms of Magnolia and/or its constituents.
玉兰树的树皮和/或球果在韩国、中国和日本传统草药医学中被使用。根据大量研究其治疗各种疾病的药理作用的研究人员数量判断，诸如厚朴酚、和厚朴酚、4-O-甲基和厚朴酚和木兰醇等生物活性成分受到了极大关注。最近，许多研究人员报道了其抗癌、抗应激、抗焦虑、抗抑郁、抗氧化、抗炎和保肝作用以及毒性和药代动力学数据，然而，这些药理活性的机制尚不清楚。本研究旨在综述各种实验和临床报告，并描述玉兰及其成分的有效性、毒性和药代动力学以及可能的作用机制。
