瓜氨酸化波形蛋白在抗瓜氨酸化蛋白抗体产生及类风湿关节炎发病机制中的相关性。
The relevance of citrullinated vimentin in the production of antibodies against citrullinated proteins and the pathogenesis of rheumatoid arthritis.
机构信息
Laboratory for Pharmaceutical Biotechnology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
出版信息
Rheumatology (Oxford). 2011 May;50(5):830-7. doi: 10.1093/rheumatology/keq419. Epub 2011 Jan 27.
Abstract
Antibodies against citrullinated proteins (ACPAs) are highly specific for RA. Since the discovery of these antibodies, several of studies that focused on the presence and identity of citrullinated proteins in the joints of RA patients have been carried out. The best-known antigens that bind ACPAs are citrullinated filaggrin, Type II collagen (CII), α-enolase, fibrinogen and vimentin. This review compares citrullinated filaggrin, CII, α-enolase and fibrinogen with vimentin in their contribution to ACPA triggering, and gives an overview of the literature in which the role of citrullinated and non-citrullinated vimentin in the onset of ACPA production and the pathogenesis of RA is discussed.
摘要
抗瓜氨酸化蛋白（ACPAs）抗体对 RA 具有高度特异性。自这些抗体被发现以来，已经进行了多项研究，重点关注 RA 患者关节中瓜氨酸化蛋白的存在和特性。结合 ACPA 的最著名的抗原是瓜氨酸化角蛋白丝、II 型胶原蛋白（CII）、α-烯醇酶、纤维蛋白原和波形蛋白。这篇综述比较了瓜氨酸化角蛋白丝、CII、α-烯醇酶和纤维蛋白原与波形蛋白在触发 ACPA 方面的作用，并概述了文献中讨论了瓜氨酸化和非瓜氨酸化波形蛋白在 ACPA 产生和 RA 发病机制中的作用。
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