Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), Marseille, France.
Institut Hospitalo-Universitaire (IHU)-Méditerranée Infection, Marseille, France.
Front Immunol. 2023 Jul 5;14:1224352. doi: 10.3389/fimmu.2023.1224352. eCollection 2023.
Vimentin is an intermediate filament protein that plays a role in cell processes, including cell migration, cell shape and plasticity, or organelle anchorage. However, studies from over the last quarter-century revealed that vimentin can be expressed at the cell surface and even secreted and that its implications in cell physiology largely exceed structural and cytoskeletal functions. Consequently, vimentin contributes to several pathophysiological conditions such as cancer, autoimmune and inflammatory diseases, or infection. In this review, we aimed at covering these various roles and highlighting vimentin implications in the immune response. We also provide an overview of how some microbes including bacteria and viruses have acquired the ability to circumvent vimentin functions in order to interfere with host responses and promote their uptake, persistence, and egress from host cells. Lastly, we discuss the therapeutic approaches associated with vimentin targeting, leading to several beneficial effects such as preventing infection, limiting inflammatory responses, or the progression of cancerous events.
波形蛋白是一种中间丝蛋白，在细胞过程中发挥作用，包括细胞迁移、细胞形状和可塑性或细胞器锚定。然而，过去四分之一个世纪的研究表明，波形蛋白可以在细胞表面表达，甚至可以分泌，其在细胞生理学中的意义在很大程度上超出了结构和细胞骨架功能。因此，波形蛋白有助于几种病理生理状况，如癌症、自身免疫和炎症性疾病或感染。在这篇综述中，我们旨在涵盖这些各种作用，并强调波形蛋白在免疫反应中的意义。我们还概述了一些微生物，包括细菌和病毒，是如何获得规避波形蛋白功能的能力，以干扰宿主反应并促进它们进入、在宿主细胞中持续存在和离开宿主细胞。最后，我们讨论了与波形蛋白靶向相关的治疗方法，这些方法带来了许多有益的效果，如预防感染、限制炎症反应或阻止癌症事件的进展。
