Evenson Kelly R
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina - Chapel Hill, 137 East Franklin Street, Suite 306, Bank of America Center, Chapel Hill, NC 27514.
Psychol Sport Exerc. 2011 Jan;12(1):36-45. doi: 10.1016/j.psychsport.2010.04.010.
The purpose of this paper was to describe the rationale, data collection, and proposed analyses for examination of mediators of change in physical activity from pregnancy to postpartum among a cohort of pregnant women. METHOD: The Pregnancy Infection and Nutrition 3 (PIN3) Study enrolled 2006 pregnant women into the cohort from 2001 to 2005. All women lived in central North Carolina upon enrollment. Physical activity was assessed using a self-reported one week recall, measured twice during pregnancy and once each at 3- and 12-months postpartum. On a subset of women, one-week accelerometer measures were also collected during the two postpartum time periods. Potential mediators (intrapersonal, interpersonal, community) were collected during pregnancy and postpartum through interviews and take home questionnaires. RESULTS: To assess mediation of physical activity among our cohort, we will first describe change in physical activity and the mediators, as well as their associations, through pregnancy into the postpartum period. Following this, the product of coefficients approach will be applied to examine whether each measure had indirect effects on change in physical activity. Each individual level mediator will be examined one at a time and across the time points in which it was available. The Sobel standard error approximation formula will be used to test for significance of the mediation effect. CONCLUSIONS: This study will provide evidence to develop appropriate interventions targeted at physical activity and will help focus efforts on the appropriate time periods between pregnancy and postpartum.
本文旨在描述对一组孕妇从孕期到产后身体活动变化的中介因素进行研究的基本原理、数据收集方法及拟采用的分析方法。方法:“孕期感染与营养3(PIN3)研究”在2001年至2005年期间招募了2006名孕妇纳入该队列。所有女性在入组时均居住在北卡罗来纳州中部。身体活动通过自我报告的一周回顾进行评估,在孕期测量两次,产后3个月和12个月各测量一次。在一部分女性中,还在产后两个时间段收集了一周的加速度计测量数据。通过访谈和家庭问卷在孕期和产后收集潜在的中介因素(个人内部、人际、社区层面)。结果:为了评估我们队列中身体活动的中介作用,我们将首先描述从孕期到产后身体活动、中介因素的变化及其关联。在此之后,将应用系数乘积法来检验每个测量指标对身体活动变化是否有间接影响。将逐一检查每个个体层面的中介因素,并在其可用的时间点进行检查。将使用索贝尔标准误差近似公式来检验中介效应的显著性。结论:本研究将为制定针对身体活动的适当干预措施提供证据,并有助于将精力集中在孕期到产后的适当时间段。