质谱分析系统的小型化
Miniaturization of Mass Spectrometry Analysis Systems.
作者信息
Xu Wei, Manicke Nicholas E, Cooks Graham R, Ouyang Zheng
机构信息
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
出版信息
JALA Charlottesv Va. 2010 Dec;15(6):433-439. doi: 10.1016/j.jala.2010.06.004.
Abstract
The key concepts and technologies developed in our laboratories in Purdue University for the miniaturization of mass spectrometry analysis systems are introduced. Mass analyzers of simple geometries with a novel atmospheric pressure interface were employed allowed reduction in the size of the ion trap mass spectrometer. Ambient ionization methods were developed and coupled to miniature mass spectrometers to allow direct MS analysis of complex samples without sample preparation and chemical separation. The performance of desorption electrospray ionization, low temperature plasma probe, paper spray as well as two handheld MS systems, Mini 10 and Mini 11, are described with demonstrations of capabilities for chemical analysis.
摘要
本文介绍了我们在普渡大学实验室中为质谱分析系统小型化所开发的关键概念和技术。采用了具有新型大气压接口的简单几何形状的质量分析器，从而减小了离子阱质谱仪的尺寸。开发了常压电离方法并将其与微型质谱仪相结合，以实现对复杂样品的直接质谱分析，无需样品制备和化学分离。文中描述了解吸电喷雾电离、低温等离子体探针、纸喷雾以及两款手持式质谱系统Mini 10和Mini 11的性能，并展示了它们的化学分析能力。
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