Department of Endocrinology, 424 Military Hospital, 4 Soulini st, 566 25, Sykies, Thessaloniki, Greece.
Pituitary. 2012 Dec;15 Suppl 1:S28-32. doi: 10.1007/s11102-011-0291-6.
We present a 22-year old male patient previously treated with radiotherapy and surgery at the age of 7 for an undefined suprachiasmatic mass. Following treatment he gradually became morbidly obese and besides subsequent panhypopituitarism he achieved his target height probably due to obesity-induced severe hyperinsulinemia. At the age of 21 Langerhans' cell histiocytosis was diagnosed at the right mandible and was surgically treated. One year later he developed a further painful osteolytic hip lesion and a single zoledronate infusion eliminated all symptoms. We highlight the importance of obtaining a histological diagnosis before initiating treatment, and the distinctive course of the disease in a patient who continued to growth besides GH deficiency.
我们报告 1 例 22 岁男性患者，7 岁时因下丘脑不明性质的肿瘤接受过放疗和手术治疗。此后，患者逐渐出现病态肥胖，且除了垂体功能减退症外，还由于肥胖引起的严重高胰岛素血症而达到了他的目标身高。21 岁时，于右侧下颌骨诊断为朗格汉斯细胞组织细胞增生症，并进行了手术治疗。1 年后，患者出现另一个疼痛性溶骨性髋关节病变，单次唑来膦酸输注消除了所有症状。我们强调在开始治疗前获得组织学诊断的重要性，以及在 GH 缺乏症患者中继续生长的情况下疾病的独特病程。
