Sápy P, Furka I, Fábián E, Mikó I, Balázs G
1st Department of Surgery, Debrecen University Medical School, Hungary.
Acta Chir Hung. 1990;31(2):145-50.
The effect of parenteral nutrition on the pancreatic secretion was studied under experimental conditions. Experiments were carried out in 24 mongrel dogs. In all animals pancreatic fistulas were created for collection of pancreatic juice. Subsequently, in three groups (6 dogs in each) parenteral nutrition via a catheter enterostomy was applied in three different segments of their small bowels, while collecting the pancreatic juice. Group IV served as control where no parenteral nutriment was administered. The amount, pH, protein and enzyme levels of the pancreatic juice secreted during 4 hours were studied in all groups. The experiments revealed that parenteral nutrition at the initial segment of the jejunum enhanced pancreatic secretion, while this was not experienced in the other groups. The effect is assumed to be humoral, rather with a secretin-like stimulation. Based on the experimental results, the authors call attention to the fact that, during treatment of acute pancreatitis, if a feeding enterostomy is constructed for calorie intake, it should not be performed within the first metre of the jejunum.
在实验条件下研究了肠外营养对胰腺分泌的影响。实验在24只杂种狗身上进行。对所有动物均造胰腺瘘以收集胰液。随后，将三组（每组6只狗）通过导管肠造口术进行肠外营养，分别应用于小肠的三个不同节段，同时收集胰液。第四组作为对照组，不给予肠外营养。研究了所有组在4小时内分泌的胰液的量、pH值、蛋白质和酶水平。实验表明，空肠起始段的肠外营养可增强胰腺分泌，而其他组未出现这种情况。这种作用被认为是体液性的，类似于促胰液素样刺激。基于实验结果，作者提请注意这样一个事实，即在急性胰腺炎的治疗过程中，如果为摄入热量而构建喂养肠造口术，不应在空肠的第一米范围内进行。
