Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas 77030, USA.
Pediatr Blood Cancer. 2011 Dec 15;57(7):1137-41. doi: 10.1002/pbc.22978. Epub 2011 Jan 28.
Mucoepidermoid carcinoma (MEC) of the salivary glands has been reported to occur in patients previously treated with chemotherapy and/or radiation. The purpose of our study is to review the patient, tumor, and treatment characteristics of patients who develop a treatment-related MEC.
A PubMed search of English language articles was performed using the keywords and MeSH terms: mucoepidermoid, salivary gland, radiation-induced, second malignancy, radiotherapy, and chemotherapy.
The search yielded 23 articles describing 58 patients who received chemotherapy and/or radiotherapy (RT) and subsequently developed MEC. The most common initial diagnoses were acute lymphoblastic leukemia (n = 18), acne (n = 9), and Hodgkin lymphoma (n = 6). Patients were divided into three groups according to chemotherapy and RT treatment: chemotherapy alone (n = 14), RT alone (n = 14), or chemotherapy and RT (n = 30). The parotid gland was the most common site for secondary MEC. Latent time (LT) to development of MEC from initial tumor treatment was significantly shorter in the patients treated with chemotherapy ± RT versus RT alone (7.9 years vs. 27.2 years, P < 0.01). The most common treatment for MEC was surgery alone followed by surgery and postoperative RT. The 2- and 5-year overall survival rates were 98% and 93.4% while the 2- and 5-year locoregional control rates were 97.7% and 92.5%, respectively. There was no difference in survival or locoregional control between groups exposed to RT alone, chemotherapy alone, or chemotherapy with RT for the initial tumor.
Radiation and chemotherapy-related MEC has an excellent prognosis.
涎腺黏液表皮样癌（MEC）已报道发生于先前接受化疗和/或放疗的患者。我们研究的目的是回顾发生治疗相关 MEC 的患者的患者、肿瘤和治疗特征。
使用关键词和 MeSH 术语，在 PubMed 上进行了英语文献的搜索：mucoepidermoid、salivary gland、radiation-induced、second malignancy、radiotherapy 和 chemotherapy。
该搜索共产生了 23 篇描述了 58 例接受化疗和/或放疗（RT）后发生 MEC 的患者的文章。最常见的初始诊断是急性淋巴细胞白血病（n = 18）、痤疮（n = 9）和霍奇金淋巴瘤（n = 6）。根据化疗和 RT 治疗，患者被分为三组：单独化疗（n = 14）、单独 RT（n = 14）或化疗加 RT（n = 30）。继发 MEC 的最常见部位是腮腺。与单独接受 RT 治疗的患者相比，接受化疗 ± RT 治疗的患者从初始肿瘤治疗到 MEC 发展的潜伏时间（LT）明显缩短（7.9 年 vs. 27.2 年，P < 0.01）。MEC 的最常见治疗方法是单纯手术，其次是手术加术后 RT。2 年和 5 年总生存率分别为 98%和 93.4%，2 年和 5 年局部区域控制率分别为 97.7%和 92.5%。单独接受 RT、单独接受化疗或初始肿瘤接受化疗加 RT 的患者在生存和局部区域控制方面无差异。
放疗和化疗相关的 MEC 具有极好的预后。
