Nikonenko B V, Mezhlumova M B, Moroz A M
Biull Eksp Biol Med. 1990 Nov;110(11):526-8.
Vaccination with M. bovis (BCG) essentially prolonged survival time (ST) of several strain mice, with the exception, of CBA/N, infected with M. tuberculosis H37Rv. ST of CBA/N, differing from CBA by xid mutation, was not prolonged by vaccination. Mouse strains with alternative alleles of BCG gene (s and r) and fzy gene as a genetic marker for Bcg5 were used for segregation analysis. It was shown that ST, the level of DTH reaction of mice infected with M. tuberculosis H37Rv, and protective effect of BCG vaccination did not depend on Bcg gene. However, Bcg gene, apparently, regulate the DTH response to PPD in mice only vaccinated with M. bovis (BCG).
用牛分枝杆菌（卡介苗）进行疫苗接种基本上延长了感染结核分枝杆菌H37Rv的几种品系小鼠的存活时间（ST），但CBA/N品系除外。与CBA品系因xid突变而不同的CBA/N品系，其存活时间并未因接种疫苗而延长。使用具有卡介苗基因（s和r）替代等位基因以及作为Bcg5基因标记的fzy基因的小鼠品系进行分离分析。结果表明，感染结核分枝杆菌H37Rv的小鼠的存活时间、迟发型超敏反应（DTH）水平以及卡介苗接种的保护作用并不依赖于Bcg基因。然而，Bcg基因显然仅在接种牛分枝杆菌（卡介苗）的小鼠中调节对结核菌素纯蛋白衍生物（PPD）的DTH反应。
