Lagrange P H, Hurtrel B, Brandely M, Stach J L
Dev Biol Stand. 1986;58 ( Pt A):25-36.
Numerous field trials of BCG vaccine, undertaken to evaluate its effectiveness in the prophylaxis of human tuberculosis, indicated that the levels of protection achieved were not uniform. Most probable factors influencing these results are: partial protection due to atypical mycobacteria, tuberculosis expectancy in different population, nutritional and socio-economic factors, potency of BCG vaccines, and genetic factors controlling the host immune response. Specific and non specific hallmarks of cell-mediated immunity after BCG infection were analysed in various outbred, inbred and recombinant lines of mice, testing the capacity of different preparations and strains of BCG vaccine. Results of such studies did show that the by far most important factor involved the type of immune response related to gene(s) controlling the natural resistance and the expression of C.M.I. Consequences for future mass and individual BCG vaccination as well as the proper integration of BCG vaccination in antituberculous policy are discussed.
为评估卡介苗在预防人类结核病方面的有效性而进行的大量现场试验表明，所实现的保护水平并不一致。影响这些结果的最可能因素有：非典型分枝杆菌引起的部分保护、不同人群的结核病预期、营养和社会经济因素、卡介苗的效力以及控制宿主免疫反应的遗传因素。在各种远交、近交和重组系小鼠中分析了卡介苗感染后细胞介导免疫的特异性和非特异性特征，测试了不同制剂和菌株的卡介苗的能力。此类研究结果确实表明，迄今为止最重要的因素涉及与控制自然抵抗力的基因相关的免疫反应类型以及细胞介导免疫的表达。讨论了对未来大规模和个体卡介苗接种的影响以及卡介苗接种在抗结核政策中的适当整合。
