Rammsayer T, Netter P
Department of Psychology, University of Gieseen, West Germany.
Int J Neurosci. 1990 Dec;55(2-4):99-106. doi: 10.3109/00207459008985955.
Conflicting results on clinical effects of serotonergic drugs gave rise to this investigation on the relationship between depression-related personality factors and effects of the 5-HT uptake inhibitor fluoxetine on psychomotor functions and emotional states. In a double-blind, balanced, crossover design, 24 healthy male subjects divided according to scales of "Experiencing of Stress" and "Neuroticism," were tested with a single dose of 60 mg fluoxetine or placebo. Reaction time and feelings of activation and energy of highly neurotic or stressed subjects were deteriorated by fluoxetine while emotionally stable subjects were improved by the drug. The findings were interpreted in terms of personality related differences in 5-HT neurotransmission and receptor sensitivity.
血清素能药物临床疗效的相互矛盾的结果引发了这项关于抑郁相关人格因素与5-羟色胺摄取抑制剂氟西汀对精神运动功能和情绪状态影响之间关系的研究。在一项双盲、均衡、交叉设计中，根据“压力体验”和“神经质”量表将24名健康男性受试者分组，分别给予单剂量60毫克氟西汀或安慰剂进行测试。氟西汀使高度神经质或压力大的受试者的反应时间以及激活感和精力感变差，而情绪稳定的受试者则因该药物而得到改善。这些发现是根据5-羟色胺神经传递和受体敏感性方面与人格相关的差异来解释的。
