Rammsayer T, Netter P
Department of Psychology, University of Giessen, West Germany.
Int Clin Psychopharmacol. 1988 Jul;3(3):231-7. doi: 10.1097/00004850-198807000-00004.
Clinical studies on fluoxetine have reported occasional symptoms of increased fatigue in depressed patients. On the other hand, experimental studies in healthy subjects have demonstrated evidence for fluoxetine-induced increases in cortical arousal. The present placebo-controlled study with 24 healthy subjects was designed to answer the following questions: Does fluoxetine increase measures of cortical arousal and decrease feelings of alertness, and does the 5HT2 receptor blocker ritanserin produce inverse effects to fluoxetine? Analyses of covariance revealed the following results: Fluoxetine produced a slight increase, ritanserin a marked decrease in critical flicker fusion frequency. Time perception was slightly improved by both drugs. Self-ratings on alertness and energy were significantly reduced by both fluoxetine and ritanserin as compared to placebo. Effects for fatigue were increased accordingly. Possible underlying neurophysiological mechanisms and specificity of the effects for cortical as opposed to limbic arousal will be discussed.
关于氟西汀的临床研究报告称，抑郁症患者偶尔会出现疲劳加剧的症状。另一方面，针对健康受试者的实验研究表明，有证据显示氟西汀会导致皮质觉醒增加。本项针对24名健康受试者的安慰剂对照研究旨在回答以下问题：氟西汀是否会提高皮质觉醒指标并降低警觉感，5-羟色胺2（5HT2）受体阻滞剂利坦色林对氟西汀是否会产生相反的作用？协方差分析得出以下结果：氟西汀使临界闪烁融合频率略有增加，利坦色林则使其显著降低。两种药物都使时间感知略有改善。与安慰剂相比，氟西汀和利坦色林均显著降低了受试者对警觉性和精力的自我评分。相应地，疲劳效应有所增加。将讨论可能的潜在神经生理机制以及皮质觉醒与边缘系统觉醒效应的特异性。
