Department of Medicine, Olive View - UCLA Medical Center, Sylmar, CA, USA.
Liver Int. 2011 Mar;31(3):291-302. doi: 10.1111/j.1478-3231.2010.02434.x. Epub 2011 Jan 11.
Liver transplant remains the ultimate treatment for decompensated liver disease. However, many diseases do recur after orthotopic liver transplant, which may affect recipients' quality of life and survival rate. We performed a systematic review of relevant epidemiological studies available on Medline that provided information on the recurrence of non-viral hepatitis after orthotopic liver transplantation in adult patients published until August 2010. All data were compiled from either review articles or retrospective studies. Primary sclerosing cholangitis, primary biliary cirrhosis, autoimmune hepatitis, non-alcoholic steatohepatitis, alcoholic steatohepatitis and haemochromatosis can recur after liver transplantation. The rates for disease recurrence varied according to the indication for transplantation, and ranged from 7 to 50%. Although the survival rate of patients with liver disease has increased with the advent of liver transplantation and novel immunosuppressive protocols, recurrence of the primary liver disease remains a concern. The recurrence rates differ not only according to the cause of underlying liver disease but also vary within the indication for transplant. Further studies are needed to elucidate the risk factors for varied disease recurrence.
肝移植仍然是治疗肝功能失代偿的最终手段。然而，许多疾病在原位肝移植后会复发，这可能会影响受者的生活质量和生存率。我们对截至 2010 年 8 月在 Medline 上可获得的有关成人患者原位肝移植后非病毒性肝炎复发的相关流行病学研究进行了系统评价，这些研究提供了有关信息。所有数据均来自综述文章或回顾性研究。原发性硬化性胆管炎、原发性胆汁性肝硬化、自身免疫性肝炎、非酒精性脂肪性肝炎、酒精性脂肪性肝炎和血色病均可在肝移植后复发。疾病复发的比率取决于移植的适应证，范围为 7%至 50%。尽管随着肝移植和新型免疫抑制方案的出现，肝病患者的生存率有所提高，但原发性肝病的复发仍然是一个令人关注的问题。复发率不仅取决于潜在肝病的原因，而且在移植适应证内也有所不同。需要进一步的研究来阐明导致不同疾病复发的危险因素。
