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[复发性肺结核患者利福平与乙胺丁醇复治的研究]

[Studies of resumption of treatment with rifampin and ethambutol in patients with recurrent pulmonary tuberculosis].

作者信息

Jozefovics F, Barbu Z, Bálinth E, Ovári A M

出版信息

Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1978 Jul-Sep;27(3):177-84.

PMID:212815
Abstract

The immediate and the late results are analyzed, of resumption of treatment with RMP and EMB in 50 patients with relapsing pulmonary tuberculosis that had not been treated with these drugs previously. After the first year of treatment negativation of the sputum by microscopy and culture was obtained in 45 of the patients, while 5 remained still positive. In the following two years 7 of the negative patients became positive again and finally 8 were solved completely and 4 became chronically ill. The most important of the unfavourable factors were simultaneous radiological and bacteriological relapses and chronic alcoholism. There was no primary or secondary resistance against the drugs used in the treatment. Intolerance to the drugs, although frequent, did not significantly affect the course of the treatment, especially because it occurred only at a later time.

摘要

对50例既往未使用过利福平(RMP)和乙胺丁醇(EMB)治疗的复发性肺结核患者重新使用这两种药物治疗后的近期和远期结果进行了分析。治疗第一年结束时,45例患者痰涂片和培养转阴,5例仍为阳性。在接下来的两年中,7例转阴患者再次转为阳性,最终8例完全治愈,4例转为慢性病。最主要的不利因素是影像学和细菌学同时复发以及慢性酒精中毒。对治疗中使用的药物没有原发性或继发性耐药。药物不耐受虽然常见,但对治疗进程没有显著影响,尤其是因为它仅在后期出现。

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