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用乙胺丁醇和利福平治疗新患和慢性结核病患者(作者译)

[Treatment of new and chronic tuberculous patients with ethambutol and Rifampicin (author's transl)].

作者信息

Pregowski W, Stanczuk A, Znaniecka H, Cesarz-Fronczyk M

出版信息

Z Erkr Atmungsorgane. 1976 May;145(2):220-6.

PMID:983179
Abstract

In patients with chronic pulmonary tuberculosis the results of chemotherapy between drug regimens containing ethambutol or rifampicin were compared. Patients in both groups were randomized selected. After 4 months of chemotherapy negativization was reached to 100% in the RMP-group compared to 80% of the patients in the EMB-group. In 98 chronics EMB was added to the chemotherapy regimen and resulted in 90% of negativization. In a small subgroup RMP was added to the regimen and 100% negativization could be obtained. Among 220 patients with chronic pulmonary tuberculosis, treated with RMP in 9 hospitals according to our protocoll, in 205 patients (93.2%) the excretion of bacilli was cessated. In 54 new cases treated with EMB and another combination and in 20 new cases treated additionally with RMP the sputum converted to negative in 100% of the patients. But the the negativization was reached 24 days earlier on the average in the group treated with RMP. Antituberculotic drugs are administered in our clinic according to the body weight.

摘要

在慢性肺结核患者中,对含乙胺丁醇或利福平的化疗方案的疗效进行了比较。两组患者均为随机选取。化疗4个月后,利福平组痰菌转阴率达100%,而乙胺丁醇组为80%。在98例慢性患者中,化疗方案中加用乙胺丁醇后痰菌转阴率达90%。在一小亚组中,化疗方案加用利福平后痰菌转阴率可达100%。在9家医院按照我们的方案对220例慢性肺结核患者使用利福平治疗,205例(93.2%)患者痰菌停止排出。在54例采用乙胺丁醇及其他联合用药治疗的新发病例和20例额外加用利福平治疗的新发病例中,100%的患者痰菌转阴。但利福平治疗组痰菌转阴平均提前24天。我们诊所根据体重给予抗结核药物。

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