Department of Social Medicine, Preventive Medicine and Nutrition Clinic, Medical School, University of Crete, Heraklion, Greece.
Pharmacol Biochem Behav. 2011 Apr;98(2):316-9. doi: 10.1016/j.pbb.2011.01.016. Epub 2011 Jan 31.
Biomarkers of Polyunsaturated Fatty Acids (PUFAs) have been related to depressive symptoms in healthy adults. It is also known that depression is high prevalent in Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and obesity. The aim of our study was to examine a possible association between PUFAs of the n-6 and n-3 families and depressive symptoms in obese OSAHS patients. Sixty three patients with OSAHS based on overnight attended polysomnography were included. Gluteal adipose tissue biopsies were performed in all participants. Fatty acids were analyzed by gas chromatography. Depressive symptoms were assessed by the Zung Self-rating Depression Scale. The majority of participants had grade II obesity (BMI: 36.2±4.3 kg/m(2)) and moderate to severe OSAHS. Mild depressive symptoms were found to affect 27.8% of the studied patients. No link between symptoms of depression and individual n-6 and/or n-3 PUFAs of gluteal adipose tissue was detected. However, multiple linear regression analysis showed a positive correlation between depressive symptoms and 20:3n-6/18:3n-6 ratio, and a negative association with age and n-6/n-3 ratio. The possible influence of OSAHS and obesity in depression development and the quiescent nature of gluteal adipose tissue may account for the absence of any significant relations between n-6 and/or n-3 PUFAs and depressive symptoms in our sample. The positive relationship between symptoms of depression and the particular fatty acid ratio probably indicates an increase in prostaglandins family although this needs further research.
多不饱和脂肪酸（PUFAs）的生物标志物与健康成年人的抑郁症状有关。此外，人们还知道，抑郁在阻塞性睡眠呼吸暂停低通气综合征（OSAHS）和肥胖症中发病率很高。我们的研究目的是检查 n-6 和 n-3 家族的多不饱和脂肪酸与肥胖 OSAHS 患者抑郁症状之间的可能关联。共有 63 名根据夜间进行的多导睡眠图诊断为 OSAHS 的患者被纳入研究。所有参与者均进行臀肌脂肪组织活检。通过气相色谱法分析脂肪酸。通过zung 自评抑郁量表评估抑郁症状。大多数参与者患有二级肥胖症（BMI：36.2±4.3 kg/m(2))和中重度 OSAHS。研究发现，27.8%的患者有轻度抑郁症状。未发现抑郁症状与臀肌脂肪组织中的个体 n-6 和/或 n-3 PUFAs 之间存在联系。然而，多元线性回归分析显示，抑郁症状与 20:3n-6/18:3n-6 比值呈正相关，与年龄和 n-6/n-3 比值呈负相关。OSAHS 和肥胖症对抑郁发展的可能影响以及臀肌脂肪组织的静止性质可能是导致我们样本中 n-6 和/或 n-3 PUFAs 与抑郁症状之间没有任何显著关系的原因。抑郁症状与特定脂肪酸比值之间的正相关关系可能表明前列腺素家族的增加，尽管这需要进一步研究。
