Xu Huajun, Zheng Xiaojiao, Jia Wei, Yin Shankai
From the Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China (HX, XZ, SY); and Center for Translational Medicine, and Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China (HX, XZ, WJ).
Medicine (Baltimore). 2015 Oct;94(40):e1541. doi: 10.1097/MD.0000000000001541.
Biomarker assessment is based on quantifying several proteins and metabolites. Recent developments in proteomics and metabolomics have enabled detection of these small molecules in biological samples and exploration of the underlying disease mechanisms in obstructive sleep apnea (OSA). This systemic review was performed to identify biomarkers, which were only detected by chromatography and/or mass spectrometry (MS) and to discuss the role of these biomarkers in the field of OSA. We systemically reviewed relevant articles from PubMed and EMBASE referring to proteins and metabolite profiles of biological samples in patients with OSA. The analytical platforms in this review were focused on chromatography and/or MS. In total, 30 studies evaluating biomarkers in patients with OSA using chromatography and/or MS methods were included. Numerous proteins and metabolites, including lipid profiles, adrenergic/dopaminergic biomarkers and derivatives, amino acids, oxidative stress biomarkers, and other micromolecules were identified in patients with OSA. Applying chromatography and/or MS methods to detect biomarkers helps develop an understanding of OSA mechanisms. More proteomic and metabolomic studies are warranted to develop potential diagnostic and clinical monitoring methods for OSA.
生物标志物评估基于对多种蛋白质和代谢物进行定量分析。蛋白质组学和代谢组学的最新进展使得能够在生物样本中检测这些小分子，并探索阻塞性睡眠呼吸暂停（OSA）潜在的疾病机制。进行这项系统评价是为了识别仅通过色谱法和/或质谱法（MS）检测到的生物标志物，并讨论这些生物标志物在OSA领域中的作用。我们系统地回顾了来自PubMed和EMBASE的相关文章，这些文章涉及OSA患者生物样本的蛋白质和代谢物谱。本评价中的分析平台主要集中在色谱法和/或质谱法。总共纳入了30项使用色谱法和/或质谱法评估OSA患者生物标志物的研究。在OSA患者中鉴定出了许多蛋白质和代谢物，包括脂质谱、肾上腺素能/多巴胺能生物标志物及其衍生物、氨基酸、氧化应激生物标志物和其他小分子。应用色谱法和/或质谱法检测生物标志物有助于深入了解OSA的机制。需要更多的蛋白质组学和代谢组学研究来开发OSA潜在的诊断和临床监测方法。
