Institute for Cognitive Science Studies (ICSS), Tehran, Iran.
Neurosci Lett. 2011 Mar 24;491(3):227-31. doi: 10.1016/j.neulet.2011.01.056. Epub 2011 Jan 31.
In the current study, cross state-dependent learning between the cannabinoid CB1/CB2 receptor agonist WIN55, 212-2 (WIN) and muscarinic receptor antagonist scopolamine (SCO) in a step-through inhibitory avoidance task was investigated. All drugs were injected bilaterally into the dorsal hippocampus (intra-CA1) of rats. Data indicated that the immediate post-training administration of WIN (0.25 and 0.5μg/rat) and SCO (2 and 4μg/rat) decreased memory consolidation and induced amnesia. Moreover, the amnesia induced by the post-training injections of WIN (0.5μg/rat) or SCO (2μg/rat) was restored by either pre-test injections of WIN (0.25 and 0.5μg/rat) or SCO (2 and 4μg/rat). Furthermore, pre-test co-administration of ineffective doses of WIN (0.1μg/rat) with SCO (1μg/rat) restored amnesia induced by the post-training injections of WIN (0.5μg/rat) or SCO (2μg/rat). In conclusion, the data strongly revealed a cross state-dependent learning between WIN and SCO in the rat dorsal hippocampus.
在当前的研究中，在一个回避性任务中，研究了大麻素 CB1/CB2 受体激动剂 WIN55,212-2（WIN）和毒蕈碱受体拮抗剂东莨菪碱（SCO）在跨状态依赖性学习中的相互作用。所有药物均双侧注射到大鼠背侧海马（CA1 内）。数据表明，WIN（0.25 和 0.5μg/rat）和 SCO（2 和 4μg/rat）在训练后即刻给药会降低记忆巩固并引起健忘症。此外，WIN（0.5μg/rat）或 SCO（2μg/rat）训练后注射引起的健忘症可通过预测试注射 WIN（0.25 和 0.5μg/rat）或 SCO（2 和 4μg/rat）恢复。此外，预测试联合给予无效剂量的 WIN（0.1μg/rat）和 SCO（1μg/rat）可恢复 WIN（0.5μg/rat）或 SCO（2μg/rat）训练后注射引起的健忘症。总之，这些数据强烈表明，WIN 和 SCO 之间存在跨状态依赖性学习关系，这一关系存在于大鼠背侧海马中。
