金黄色葡萄球菌导致儿童反复发生皮肤和软组织感染的莫匹罗星耐药性。
Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children.
机构信息
Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Feigin Center, Suite 1150, 1102 Bates St., Houston, TX 77030, USA.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2431-3. doi: 10.1128/AAC.01587-10. Epub 2011 Jan 31.
Abstract
Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene mupA. We tested S. aureus isolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). Fifteen isolates (11%) carried mupA, and the gene was more common in methicillin-susceptible S. aureus (21.4%) than methicillin-resistant S. aureus (8.3%; P=0.03). Seven of 20 mupirocin-resistant isolates displayed clindamycin resistance.
摘要
金黄色葡萄球菌对莫匹罗星的耐药性通常是由于质粒基因 mupA 编码的新型异亮氨酸 tRNA 合成酶的获得引起的。我们检测了德克萨斯儿童医院复发性皮肤和软组织感染患儿的金黄色葡萄球菌分离株的莫匹罗星耐药性和 mupA。在 136 株分离株中，有 20 株对莫匹罗星耐药（14.7%）。15 株（11%）携带 mupA，该基因在甲氧西林敏感金黄色葡萄球菌（21.4%）中比甲氧西林耐药金黄色葡萄球菌（8.3%）更为常见（P=0.03）。20 株莫匹罗星耐药分离株中有 7 株表现出克林霉素耐药性。
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