Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Dent Mater J. 2011;30(1):14-20. doi: 10.4012/dmj.2010-087. Epub 2011 Jan 26.
Carbonate apatite (CO(3)Ap) foam may be an ideal bone substitute as it is sidelined to cancellous bone with respect to its chemical composition and structure. However, CO(3)Ap foam fabricated using α-tricalcium phosphate foam showed limited mechanical strength. In the present study, feasibility of the fabrication of calcite which could be a precursor of CO(3)Ap was studied. Calcite foam was successfully fabricated by the so-called "ceramic foam" method using calcium hydroxide coated polyurethane foam under CO(2)+O(2) atmosphere. Then the calcite foam was immersed in Na(2)HPO(4) aqueous solution for phase transformation based on dissolution-precipitation reaction. When CaO-free calcite foam was immersed in Na(2)HPO(4) solution, low-crystalline CO(3)Ap foam with 93-96% porosity and fully interconnected porous structure was fabricated. The compressive strength of the foam was 25.6 ± 6 kPa. In light of these results, we concluded that the properties of the precursor foam were key factors for the fabrication of CO(3)Ap foams.
碳酸磷灰石（CO(3)Ap）泡沫可能是一种理想的骨替代物，因为它在化学成分和结构上与松质骨相似。然而，使用α-磷酸三钙泡沫制造的 CO(3)Ap 泡沫表现出有限的机械强度。在本研究中，研究了制备可以作为 CO(3)Ap 前体的方解石的可行性。通过在 CO(2)+O(2)气氛下使用涂覆有氢氧化钙的聚氨酯泡沫，采用所谓的“陶瓷泡沫”法成功制备了方解石泡沫。然后将方解石泡沫浸入 Na(2)HPO(4)水溶液中，通过溶解-沉淀反应进行相转化。当将无 CaO 的方解石泡沫浸入 Na(2)HPO(4)溶液中时，可制备出具有 93-96%孔隙率和完全连通多孔结构的低结晶 CO(3)Ap 泡沫。泡沫的抗压强度为 25.6±6kPa。鉴于这些结果，我们得出结论，前体泡沫的性质是制备 CO(3)Ap 泡沫的关键因素。
