聚乳酸-羟基乙酸共聚物（PLGA）浓度对碳酸磷灰石泡沫结构和力学性能的影响。

Influence of PLGA concentrations on structural and mechanical properties of carbonate apatite foam.

作者信息

Munar Girlie M, Munar Melvin L, Tsuru Kanji, Ishikawa Kunio

机构信息

Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

出版信息

Dent Mater J. 2013;32(4):608-14. doi: 10.4012/dmj.2013-031.

DOI:10.4012/dmj.2013-031

PMID:23903643

Abstract

Reinforcement with bioresorbable polymer such as PLGA is one of the useful ways to improve the mechanical property of brittle carbonate apatite (CO3Ap) foam. In the present study, CO3Ap foam was reinforced with various concentrations of PLGA solution (5, 10, 15 and 20 wt%) using vacuum infiltration method and its influence on structure, porosity and mechanical property was investigated. It was found that the amount of PLGA inside the hollow space of the CO3Ap foam strut increased with the concentration of PLGA. Porosity likewise was significantly (p<0.05) reduced from 94% (CO3Ap foam without PLGA) down to 82% (CO3Ap foam reinforced with 20 wt% PLGA). Compressive strength of CO3Ap foam significantly (p<0.05) increased from 0.02 MPa (CO3Ap foam without PLGA) up to 1.5 MPa (CO3Ap foam reinforced with 20 wt% PLGA).

摘要

用聚乳酸-羟基乙酸共聚物（PLGA）等生物可吸收聚合物增强是改善脆性碳酸磷灰石（CO3Ap）泡沫材料力学性能的有效方法之一。在本研究中，采用真空浸渍法用不同浓度（5%、10%、15%和20%重量）的PLGA溶液增强CO3Ap泡沫，并研究其对结构、孔隙率和力学性能的影响。结果发现，CO3Ap泡沫支柱中空空间内的PLGA含量随PLGA浓度的增加而增加。孔隙率同样显著（p<0.05）降低，从94%（不含PLGA的CO3Ap泡沫）降至82%（用20%重量PLGA增强的CO3Ap泡沫）。CO3Ap泡沫的抗压强度显著（p<0.05）提高，从0.02MPa（不含PLGA的CO3Ap泡沫）提高到1.5MPa（用20%重量PLGA增强的CO3Ap泡沫）。